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Tumor Protein p73 抗体 (AA 1-198)

TP73 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3043469
发货至: 中国
  • 抗原 See all Tumor Protein p73 (TP73) 抗体
    Tumor Protein p73 (TP73) (Tumor Protein P73 (TP73))
    抗原表位
    • 26
    • 15
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    AA 1-198
    适用
    • 132
    • 61
    • 35
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    人, 小鼠, 大鼠
    宿主
    • 125
    • 8
    克隆类型
    • 117
    • 16
    多克隆
    标记
    • 67
    • 8
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    This Tumor Protein p73 antibody is un-conjugated
    应用范围
    • 81
    • 39
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    • 21
    • 10
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    • 6
    • 2
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    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    原理
    Rabbit IgG polyclonal antibody for Tumor protein p73(TP73) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    交叉反应 (详细)
    No cross reactivity with other proteins.
    产品特性
    Rabbit IgG polyclonal antibody for Tumor protein p73(TP73) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Gene Name: tumor protein p73
    Protein Name: Tumor protein p73
    纯化方法
    Immunogen affinity purified.
    免疫原
    E.coli-derived human p73 recombinant protein (Position: M1-E198). Human p73 shares 96% amino acid (aa) sequence identity with mouse p73.
    亚型
    IgG
    Top Product
    Discover our top product TP73 Primary Antibody
  • 应用备注
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for p73 is approximately 0.25 ng/lane under reducing conditions.
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    浓度
    500 μg/mL
    缓冲液
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Guo, Nan, Hu, Meng, Hui, Zhang, Qin, Sui: "Prognostic significance of co-expression of nm23 and p57 protein in hepatocellular carcinoma." in: Hepatology research : the official journal of the Japan Society of Hepatology, Vol. 40, Issue 11, pp. 1107-16, (2010) (PubMed).

    Qin, Nan, Yang, Jing, Ruan, Li, Xu, Guo, Sui, Wei: "Expression and clinical significance of TAp73alpha, p53, PCNA and apoptosis in hepatocellular carcinoma." in: World journal of gastroenterology, Vol. 11, Issue 18, pp. 2709-13, (2005) (PubMed).

  • 抗原
    Tumor Protein p73 (TP73) (Tumor Protein P73 (TP73))
    别名
    TP73 (TP73 产品)
    别名
    P73 antibody, Trp73 antibody, TP73 antibody, tp73 antibody, Tp73 antibody, p73 antibody, TAp73 antibody, zp73theta antibody, tumor protein p73 antibody, transformation related protein 73 antibody, TP73 antibody, Tp73 antibody, tp73 antibody, Trp73 antibody
    背景
    P73, also known as tumor protein 73(TP73), encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It is mapped to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Furthermore, recent finding are suggesting that over-expression of transcription factors involved in cell cycle regulation and synthesis of DNA in mammalian cells (e.g.: E2F-1) induces the expression of p73. In addition, p73 is a substrate of the c-Abl kinase and that the ability of c-Abl to phosphorylate p73 is markedly increased by gamma-irradiation.

    Synonyms: p53 like transcription factor antibody|p53 Related Protein antibody|p53 Related Protein antibody|p53-like transcription factor antibody|p53-related protein antibody|p73 antibody|P73_HUMAN antibody|TP 73 antibody|TP73 antibody|TP73 antibody|Tumor Protein p73 antibody|Tumor Protein p73 antibody
    基因ID
    7161
    UniProt
    O15350
    途径
    Regulation of Cell Size, Positive Regulation of Response to DNA Damage Stimulus
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