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Lamin A/C 抗体 (AA 481-646)

Name: Lamin A/C 抗体 (AA 481-646)
SKU: ABIN3043295
Availability: OutOfStock

There are 3+ publications for this product available. The 兔多克隆 anti-Lamin A/C antibody is suitable to detect Lamin A/C in samples from 人, 小鼠和大鼠. It has been validated for WB, IHC, IF, ICC 和 FACS.

Anti- Lamin A Picoband antibody, Western blottingAll lanes: Anti Lamin A at 0. (Lamin A/C 抗体 (AA 481-646))

Anti- Lamin A Picoband antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue (Lamin A/C 抗体 (AA 481-646))

IHC

Anti- Lamin A Picoband antibody, ICC ICC: A549 Cell (Lamin A/C 抗体 (AA 481-646))

IHC

Anti- Lamin A Picoband antibody, IHC(P) IHC(P): Rat Intestine Tissue (Lamin A/C 抗体 (AA 481-646))

IHC

Anti- Lamin A Picoband antibody, IHC(P) IHC(P): Mouse Intestine Tissue (Lamin A/C 抗体 (AA 481-646))

IHC

5 images

(3 references)

产品编号 ABIN3043295

发货至: 中国

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Quick Overview for Lamin A/C 抗体 (AA 481-646) (ABIN3043295)

抗原

See all Lamin A/C (LMNA) 抗体

Lamin A/C (LMNA)

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This Lamin A/C antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Discover our top product LMNA Primary Antibody

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AA 481-646

原理

Anti-Lamin A+C/LMNA Antibody

特异性

No cross reactivity with other proteins.

交叉反应（详细）

No cross-reactivity with other proteins

预测反应

Human Lamin A,C shares 90%,92% amino acid (aa) sequence identity with mouse,rat Lamin A,C,respectively.

产品特性

Anti-Lamin A+C/LMNA Antibody. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.

纯化方法

Immunogen affinity purified.

免疫原

E.coli-derived human Lamin A/C recombinant protein (Position: Y481-Y646). Human Lamin A/C shares 90% and 92% amino acid (aa) sequence identity with mouse and rat Lamin A/C, respectively.

亚型

IgG
anti-Lamin A/C (LMNA) (AA 403-572) antibody
LMNA 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated

anti-Lamin A/C (LMNA) antibody
KO Validated LMNA 适用: 人 WB, IF, ICC, IP, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Lamin A/C (LMNA) (pSer392) antibody
LMNA 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ELISA, ICC 宿主: 兔 Polyclonal unconjugated

anti-Lamin A/C (LMNA) antibody
LMNA 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 小鼠 Monoclonal 4E7 unconjugated

anti-Lamin A/C (LMNA) antibody
LMNA 适用: 人 IHC, IF, ELISA, IP, FACS 宿主: 兔 Monoclonal 4H7 unconjugated Recombinant Antibody

anti-Lamin A/C (LMNA) (AA 1-664) antibody
LMNA 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated

anti-Lamin A/C (LMNA) (C-Term) antibody
LMNA 适用: 人, 小鼠, 大鼠, Cow, Pig, 犬, 猴, 兔, 马, Hamster, 小鸡, 绵羊, 豚鼠, Avian, Cat, 驴, 山羊 WB, IF 宿主: 山羊 Polyclonal unconjugated

anti-Lamin A/C (LMNA) (AA 400-450) antibody
LMNA 适用: 人, 小鼠 WB, IP, IF/ICC, IHC (fp) 宿主: 兔 Polyclonal unconjugated

anti-Lamin A/C (LMNA) antibody
LMNA 适用: 人, 小鼠, 大鼠, Cow, 犬 WB, IHC, ICC, FACS, IHC (fro) 宿主: 小鼠 Monoclonal 133A2 unconjugated

anti-Lamin A/C (LMNA) (AA 455-469) antibody
LMNA 适用: 人, 小鼠, 大鼠 WB, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated

应用备注

Western blot, 0.1-0.5 μg/mL, Human Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human, Mouse Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and ICC.

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, and 0.05 mg Sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

有效期

12 months
Jevti?, Edens, Li, Nguyen, Chen, Levy: "Concentration-dependent Effects of Nuclear Lamins on Nuclear Size in Xenopus and Mammalian Cells." in: The Journal of biological chemistry, Vol. 290, Issue 46, pp. 27557-71, (2015) (PubMed).

Liu, Ma, Wu, Li, Zhang, Han, Wang, Reindl, Wu, Ma: "Arginine deiminase augments the chemosensitivity of argininosuccinate synthetase-deficient pancreatic cancer cells to gemcitabine via inhibition of NF-?B signaling." in: BMC cancer, Vol. 14, pp. 686, (2014) (PubMed).

Yang, Liu, Zhu, Zhang, Xi, Hu, He, Jiang: "Human peripheral nerve-derived scaffold for tissue-engineered nerve grafts: histology and biocompatibility analysis." in: Journal of biomedical materials research. Part B, Applied biomaterials, Vol. 96, Issue 1, pp. 25-33, (2010) (PubMed).
抗原

Lamin A/C (LMNA)

别名

LMNA

背景

Background: Lamins are structural protein components of the nuclear lamina, a protein network underlying the inner nuclear membrane that determines nuclear shape and size. There are three types of lamins, A,B and C. The lamin A/C (LMNA) gene contains 12 exons. Alternative splicing within exon 10 gives rise to two different mRNAs that code for pre-lamin A and lamin C. Lamin A/C is mapped to 1q21.2-q21.3 and mutations in this gene cause a variety of human diseases including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy, and Hutchinson-Gilford progeria syndrome. Lamin A/C deficiency is thus associated with both defective nuclear mechanics and impaired mechanically activated gene transcription.
Gene Full Name: lamin A/C
Sequence Similarities: Belongs to the intermediate filament family.

分子量

74 kDa, 63 kDa

基因ID

4000

UniProt

P02545

途径

Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus