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GLI2 抗体 (C-Term)

GLI2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3042988
发货至: 中国
  • 抗原 See all GLI2 抗体
    GLI2 (GLI Family Zinc Finger 2 (GLI2))
    抗原表位
    • 7
    • 7
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1444-1463, C-Term
    适用
    • 40
    • 12
    • 4
    • 1
    • 1
    宿主
    • 39
    • 2
    • 1
    克隆类型
    • 40
    • 2
    多克隆
    标记
    • 18
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    This GLI2 antibody is un-conjugated
    应用范围
    • 15
    • 10
    • 9
    • 5
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB)
    原理
    Rabbit IgG polyclonal antibody for Zinc finger protein GLI2(GLI2) detection. Tested with WB in Human.
    序列
    MLYYYGQIHM YEQDGGLENL
    交叉反应 (详细)
    No cross reactivity with other proteins.
    产品特性
    Rabbit IgG polyclonal antibody for Zinc finger protein GLI2(GLI2) detection. Tested with WB in Human.
    Gene Name: GLI family zinc finger 2
    Protein Name: Zinc finger protein GLI2
    纯化方法
    Immunogen affinity purified.
    免疫原
    A synthetic peptide corresponding to a sequence at the C-terminus of human Gli2(1444-1463aa MLYYYGQIHMYEQDGGLENL).
    亚型
    IgG
    Top Product
    Discover our top product GLI2 Primary Antibody
  • 应用备注
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for GLI2 is approximately 0.5 ng/lane under reducing conditions.
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
    Other applications have not been tested. Optimal dilutions should be determined by end users.
    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    浓度
    500 μg/mL
    缓冲液
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    储存液
    Thimerosal (Merthiolate), Sodium azide
    注意事项
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
    有效期
    12 months
  • Xiang, Jiang, Guo, Gong, Yang, Wu, Huang, Cheng, Xu: "Hedgehog pathway inhibitor-4 suppresses malignant properties of chondrosarcoma cells by disturbing tumor ciliogenesis." in: Oncology reports, Vol. 32, Issue 4, pp. 1622-30, (2014) (PubMed).

  • 抗原
    GLI2 (GLI Family Zinc Finger 2 (GLI2))
    别名
    GLI2 (GLI2 产品)
    别名
    HPE9 antibody, THP1 antibody, THP2 antibody, GLI2/GLI4 antibody, GLI3 antibody, AW546128 antibody, GLI family zinc finger 2 antibody, GLI-Kruppel family member GLI2 antibody, GLI2 antibody, Gli2 antibody
    背景
    GLI2(Gli-Kruppel Family Member 2), also called ONCOGENE GLI2, is a protein that in humans is encoded by the GLI2 gene. Sequencing of GLI cDNA clones showed the presence of 5 tandem zinc fingers connected by histidine-cysteine links, which indicated that the gene belongs to the family of zinc finger genes related to Kruppel(Kr). The Drosophila gene Kr is a member of the gap class of segmentation genes, thoracic and anterior abdominal segments fail to form in Kr mutant embryos. By fluorescence in situ hybridization, Matsumoto et al.(1996) refined the assignment of the GLI2 gene to chromosome 2q14. Roessler et al.(2005) showed that GLI2-delta-N exhibited potent transcriptional activity in vivo: overexpression in mouse skin led to the formation of hedgehog-independent epithelial downgrowths resembling basal cell carcinomas, which in humans are associated with constitutive hedgehog signaling.

    Synonyms: Gli 2 antibody|GLI family zinc finger 2 antibody|GLI kruppel family member 2 antibody|GLI Kruppel family member GLI2 antibody|GLI2 antibody|GLI2_HUMAN antibody|Oncogene GLI2 antibody|Tax helper protein antibody|Tax helper protein 2 antibody|Tax responsive element 2 holding protein antibody|Tax responsive element 25 bp sequence binding protein antibody|THP 2 antibody|THP antibody|THP2 antibody|Zinc finger protein GLI2 antibody
    UniProt
    P10070
    途径
    Hedgehog Signaling, Dopaminergic Neurogenesis
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