Factor VIII 抗体 (Middle Region)
(15 references)Quick Overview for Factor VIII 抗体 (Middle Region) (ABIN3042924)
抗原
See all Factor VIII (F8) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1264-1278, Middle Region
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原理
- Anti-Factor VIII/F8 Antibody Picoband®
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序列
- APVLQDFRSL NDSTN
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
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Rabbit IgG polyclonal antibody for Coagulation factor VIII(F8) detection. Tested with WB in Human.
Gene Name: coagulation factor VIII, procoagulant component
Protein Name: Coagulation factor VIII -
纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence in the middle region of human Factor VIII.
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亚型
- IgG
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anti-Coagulation Factor VIII (F8) (AA 2253-2346) antibody
F8 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor VIII (F8) (AA 1887-2044) antibodyF8 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor VIII (F8) (AA 1854-1988) antibodyF8 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor VIII (F8) (AA 1451-1550) antibodyF8 适用: 人, 小鼠 ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor VIII (F8) (AA 85-190) antibodyF8 适用: 人, 小鼠, 大鼠 ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor VIII (F8) (AA 401-500) antibodyF8 适用: 人, 小鼠, 大鼠, 兔 ELISA, ICC, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor VIII (F8) (AA 1-216) antibodyF8 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor VIII (F8) (AA 213-312) antibodyF8 适用: 人 ELISA, PLA 宿主: 小鼠 Monoclonal 1E8 unconjugated
anti-Coagulation Factor VIII (F8) (AA 399-730) antibodyF8 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor VIII (F8) (AA 2191-2337) antibodyF8 适用: 犬 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
1. Hoyer, L. W. Hemophilia A. New Eng. J. Med. 330: 38-45, 1994. 2. Tantravahi, U., Murty, V. V. V. S., Jhanwar, S. C., Toole, J. J., Woozney, J. M., Chaganti, R. S. K., Latt, S. A. Physical mapping of the factor VIII gene proximal to two polymorphic DNA probes in human chromosome band Xq28: implications for factor VIII gene segregation analysis. Cytogenet. Cell Genet. 42: 75-79, 1986. 3. Toole, J. J., Knopf, J. L., Wozney, J. M., Sultzman, L. A., Buecker, J. L., Pittman, D. D., Kaufman, R. J., Brown, E., Shoemaker, C., Orr, E. C., Amphlett, G. W., Foster, W. B., Coe, M. L., Knutson, G. J., Fass, D. N., Hewick, R. M. Molecular cloning of a cDNA encoding human antihaemophilic factor. Nature 312: 342-347, 1984. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
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储存液
- Thimerosal (Merthiolate), Sodium azide
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注意事项
- This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. -
有效期
- 12 months
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: "A ferulic acid (FA)-eluting system for biodegradable magnesium stent: Cells response of HUVECs." in: Journal of biomedical materials research. Part A, Vol. 103, Issue 8, pp. 2758-69, (2015) (PubMed).
: "Angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas axis prevents lipopolysaccharide-induced apoptosis of pulmonary microvascular endothelial cells by inhibiting JNK/NF-?B pathways." in: Scientific reports, Vol. 5, pp. 8209, (2015) (PubMed).
: "Effects of transforming growth factor-?2 on myocilin expression and secretion in human primary cultured trabecular meshwork cells." in: International journal of clinical and experimental pathology, Vol. 7, Issue 8, pp. 4827-36, (2014) (PubMed).
: "Effects of chronic exposure to cigarette smoke on canonical transient receptor potential expression in rat pulmonary arterial smooth muscle." in: American journal of physiology. Cell physiology, Vol. 306, Issue 4, pp. C364-73, (2014) (PubMed).
: "Cardiomyocyte differentiation induced in cardiac progenitor cells by cardiac fibroblast-conditioned medium." in: Experimental biology and medicine (Maywood, N.J.), Vol. 239, Issue 5, pp. 628-37, (2014) (PubMed).
: "Coordinated regulation of autophagy and apoptosis determines endothelial cell fate during Dengue virus type 2 infection." in: Molecular and cellular biochemistry, Vol. 397, Issue 1-2, pp. 157-65, (2014) (PubMed).
: "Transforming growth factor ?1 induces the expression of collagen type I by DNA methylation in cardiac fibroblasts." in: PLoS ONE, Vol. 8, Issue 4, pp. e60335, (2013) (PubMed).
: "Vascularized bone tissue formation induced by fiber-reinforced scaffolds cultured with osteoblasts and endothelial cells." in: BioMed research international, Vol. 2013, pp. 854917, (2013) (PubMed).
: "Somatostatin receptors SSTR2 and SSTR5 are expressed in the human thoracic duct." in: Lymphology, Vol. 44, Issue 1, pp. 21-8, (2011) (PubMed).
: "A study of the distribution and density of the VEGFR-2 receptor on glioma microvascular endothelial cell membranes." in: Cellular and molecular neurobiology, Vol. 31, Issue 5, pp. 687-94, (2011) (PubMed).
: "Role of src-suppressed C kinase substrate in rat pulmonary microvascular endothelial hyperpermeability stimulated by inflammatory cytokines." in: Inflammation research : official journal of the European Histamine Research Society ... [et al.], Vol. 59, Issue 11, pp. 949-58, (2010) (PubMed).
: "Interleukin-17F-induced pulmonary microvascular endothelial monolayer hyperpermeability via the protein kinase C pathway." in: The Journal of surgical research, Vol. 162, Issue 1, pp. 110-21, (2010) (PubMed).
: "Proteomic analysis of primary porcine endothelial cells after infection by classical swine fever virus." in: Biochimica et biophysica acta, Vol. 1804, Issue 9, pp. 1882-8, (2010) (PubMed).
: "Identification and characterization of cancer stem-like cells from primary carcinoma of the cervix uteri." in: Oncology reports, Vol. 22, Issue 5, pp. 1129-34, (2009) (PubMed).
: "Inhibitory effect of antisense vascular endothelial growth factor RNA on the profile of hepatocellular carcinoma cell line in vitro and in vivo." in: World journal of gastroenterology, Vol. 12, Issue 7, pp. 1140-3, (2006) (PubMed).
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: "A ferulic acid (FA)-eluting system for biodegradable magnesium stent: Cells response of HUVECs." in: Journal of biomedical materials research. Part A, Vol. 103, Issue 8, pp. 2758-69, (2015) (PubMed).
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- Factor VIII (F8) (Coagulation Factor VIII (F8))
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别名
- F8
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背景
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Synonyms: Coagulation factor VIII,Antihemophilic factor,AHF,Procoagulant component,Factor VIIIa heavy chain, 200 kDa isoform,Factor VIIIa heavy chain, 92 kDa isoform,Factor VIII B chain,Factor VIIIa light chain,F8,F8C,
Background: Coagulation Factor VIII (FVIII) is an essential blood-clotting protein, also known as anti-hemophilic factor (AHF). By in situ hybridization, Tantravahi et al. (1986) concluded that the F8 gene is located in the proximal part of chromosome Xq28 with probes DX13 and St14 distally located. The F8 gene encodes coagulation factor VIII, a large plasma glycoprotein that functions in the blood coagulation cascade as a cofactor for the factor IXa-dependent activation of factor X (F10). Factor VIII is activated proteolytically by a variety of coagulation enzymes, including thrombin (F2). Factor VIII is tightly associated in the blood with von Willebrand factor (VWF), which serves as a protective carrier protein for factor VIII (Toole et al., 1984, Hoyer, 1994).
Sequence Similarities: Belongs to the multicopper oxidase family.
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分子量
- 92 kDa
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UniProt
- P00451
抗原
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