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c-MET 抗体 (AA 208-407)

Name: c-MET 抗体 (AA 208-407)
SKU: ABIN3042360
Availability: OutOfStock

Cited in 3+ publications. The 兔多克隆 anti-c-MET antibody (ABIN3042360) specifically detects c-MET in WB. The antibody is reactive with 人和大鼠 samples.

Observed bind size: 154KD (c-MET 抗体 (AA 208-407))

1 image

(3 references)

产品编号 ABIN3042360

发货至: 中国

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Quick Overview for c-MET 抗体 (AA 208-407) (ABIN3042360)

抗原

See all c-MET (MET) 抗体

c-MET (MET) (Met Proto-Oncogene (MET))

适用

人, 大鼠

宿主

兔

克隆类型

多克隆

标记

This c-MET antibody is un-conjugated

应用范围

Western Blotting (WB)

Discover our top product MET Primary Antibody

抗原表位
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AA 208-407

原理

Anti-Met (c-Met) Antibody

特异性

No cross reactivity with other proteins.

交叉反应（详细）

No cross-reactivity with other proteins

预测反应

Human Met shares 90%,91% amino acid (aa) sequences identity with mouse,rat Met,respectively.

产品特性

Anti-Met (c-Met) Antibody. Tested in WB applications. This antibody reacts with Human, Rat.

纯化方法

Immunogen affinity purified.

免疫原

E.coli-derived human Met recombinant protein (Position: D208-S407). Human Met shares 90% and 91% amino acid (aa) sequences identity with mouse and rat Met, respectively.

亚型

IgG
anti-Met Proto-Oncogene (MET) (AA 25-150) antibody
MET 适用: 人, 小鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Met Proto-Oncogene (MET) (C-Term) antibody
MET 适用: 人 WB, IHC, FACS, ICC, IP 宿主: 兔 Monoclonal BLR283L unconjugated Recombinant Antibody

anti-Met Proto-Oncogene (MET) (AA 743-932) antibody
MET 适用: 人, 猴 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 5E9C4 unconjugated

anti-Met Proto-Oncogene (MET) (AA 1092-1379) antibody
MET 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Met Proto-Oncogene (MET) (AA 743-932) antibody
MET 适用: 人 ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 5E9B7 unconjugated

anti-Met Proto-Oncogene (MET) antibody
MET 适用: 人 WB, ELISA, IHC, IF, FACS 宿主: 兔 Monoclonal 2D12 unconjugated Recombinant Antibody

anti-Met Proto-Oncogene (MET) (C-Term) antibody
MET 适用: 人 WB, IF, ICC, IP 宿主: 兔 Polyclonal unconjugated

anti-Met Proto-Oncogene (MET) (Internal Region) antibody
MET 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Met Proto-Oncogene (MET) (AA 1-1390) antibody
MET 适用: 人 WB, PLA 宿主: 小鼠 Polyclonal unconjugated

anti-Met Proto-Oncogene (MET) (pTyr1234) antibody
MET 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

Western blot, 0.1-0.5 μg/mL, Rat, Human

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, and 0.05 mg Sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

有效期

12 months
Chen, Ding, Gao, Sun, Zhang, Du, Qiu, Wang, Zheng, Sun, Ni, Feng, Zhu: "A human anti-c-Met Fab fragment conjugated with doxorubicin as targeted chemotherapy for hepatocellular carcinoma." in: PLoS ONE, Vol. 8, Issue 5, pp. e63093, (2013) (PubMed).

Bin, Ma, Xu, Shi: "Embryonic hepatocyte transplantation for hepatic cirrhosis: efficacy and mechanism of action." in: World journal of gastroenterology, Vol. 18, Issue 4, pp. 309-22, (2012) (PubMed).

Chen, Wang, Guo, Yu, Burnstock, He, Xiang, Zheng: "Expression of P2Y(6) receptors in the developing mouse skeletal muscle and after injury and repair." in: Journal of anatomy, Vol. 218, Issue 6, pp. 643-51, (2011) (PubMed).
抗原

c-MET (MET) (Met Proto-Oncogene (MET))

别名

MET

背景

Background: c-Met, also called MET and hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene. It is mapped to 7q31.2. The protein possesses tyrosine kinase activity. MET is a membrane receptor that is essential for embryonic development and wound healing. It induces several biological responses that collectively give rise to a program known as invasive growth. MET is deregulated in many types of human malignancies, including cancers of kidney, liver, stomach, breast, and brain. Normally, only stem cells and progenitor cells express MET, which allows these cells to grow invasively in order to generate new tissues in an embryo or regenerate damaged tissues in an adult. However, cancer stem cells are thought to hijack the ability of normal stem cells to express MET, and thus become the cause of cancer persistence and spread to other sites in the body.
Gene Full Name: MET proto-oncogene, receptor tyrosine kinase
Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family.

分子量

154 kDa

基因ID

4233

UniProt

P08581

途径

RTK signaling, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor