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Beclin 1 抗体 (AA 1-354)

BECN1 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

Western Blotting (WB) image for anti-Beclin 1, Autophagy Related (BECN1) (AA 1-354) antibody (ABIN3042322) (Beclin 1 抗体 (AA 1-354))

Anti-Beclin 1 Picoband antibody, IHC(P): Rat Spleen Tissue (Beclin 1 抗体 (AA 1-354))

Anti-Beclin 1 Picoband antibody, IHC(P): Rat Intestine Tissue (Beclin 1 抗体 (AA 1-354))

Anti-Beclin 1 Picoband antibody, IHC(P): Mouse Intestine Tissue (Beclin 1 抗体 (AA 1-354))

Anti-Beclin 1 Picoband antibody, IHC(P): Mouse Spleen Tissue (Beclin 1 抗体 (AA 1-354))

5 images

(7 references)

产品编号 ABIN3042322

发货至: 中国

Datasheet as PDF

抗原 See all Beclin 1 (BECN1) 抗体

Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))
抗原表位
16

15

13

9

9

9

8

8

8

8

7

7

7

6

6

6

6

6

6

6

6

5

3

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 1-354
适用
195

85

70

9

8

7

5

4

4

3

3

2

2

1

1
人, 小鼠, 大鼠
宿主
160

38

2
兔
Compatible Secondaries
克隆类型
161

39
多克隆
标记
90

17

15

14

13

13

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1
This Beclin 1 antibody is un-conjugated
应用范围
140

94

58

37

29

26

23

22

17

13

12

4

3

2
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

原理

Rabbit IgG polyclonal antibody for Beclin-1(BECN1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

交叉反应（详细）

No cross reactivity with other proteins.

产品特性

Rabbit IgG polyclonal antibody for Beclin-1(BECN1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: beclin 1, autophagy related
Protein Name: Beclin-1

纯化方法

Immunogen affinity purified.

免疫原

E.coli-derived human Beclin 1 recombinant protein (Position: M1-S354). Human Beclin 1 shares 97% amino acid (aa) sequence identity with both mouse and rat Beclin 1.

亚型

IgG

Top Product

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anti-Beclin 1, Autophagy Related (BECN1) (AA 201-330) antibody
BECN1 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), ICC, IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Beclin 1, Autophagy Related (BECN1) antibody
BECN1 适用: 人, 大鼠, 犬 WB, IHC, IF, FACS, IHC (p) 宿主: 小鼠 Monoclonal 1F1 unconjugated

anti-Beclin 1, Autophagy Related (BECN1) antibody
BECN1 适用: 人, 大鼠, 猴 WB, IHC, IF, FACS, IHC (p) 宿主: 小鼠 Monoclonal 3F3 unconjugated

anti-Beclin 1, Autophagy Related (BECN1) antibody
BECN1 适用: 人, 大鼠, 猴, 犬 WB, IHC, IF, FACS, IHC (p) 宿主: 小鼠 Monoclonal 3C3 unconjugated

anti-Beclin 1, Autophagy Related (BECN1) antibody
BECN1 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 2A4 unconjugated

anti-Beclin 1, Autophagy Related (BECN1) (AA 210-239) antibody
BECN1 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB7463 unconjugated

anti-Beclin 1, Autophagy Related (BECN1) (AA 210-239) antibody
BECN1 适用: 人, 小鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated

anti-Beclin 1, Autophagy Related (BECN1) (C-Term) antibody
BECN1 适用: 人, 小鼠 WB, ELISA, IHC, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

anti-Beclin 1, Autophagy Related (BECN1) (AA 181-210) antibody
BECN1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Beclin 1, Autophagy Related (BECN1) (AA 95-132) antibody
BECN1 适用: 人, 小鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated

应用备注

WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for Beclin 1 is approximately 0.25 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Mouse, Rat, Predicted Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C/-20 °C

储存方法

At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
Song, Hu, Li, Zheng, Wang, Guo, Shi, Liu: "Suppression of the toll-like receptor 7-dependent type I interferon production pathway by autophagy resulting from enterovirus 71 and coxsackievirus A16 infections facilitates their replication." in: Archives of virology, Vol. 163, Issue 1, pp. 135-144, (2018) (PubMed).

Wang, Dai, Song, Zhu, Liu, Hou, Ke, Zhou, Qiu, Wang, Jiang, Jia, Feng: "Lactone Component From Ligusticum chuanxiong Alleviates Myocardial Ischemia Injury Through Inhibiting Autophagy." in: Frontiers in pharmacology, Vol. 9, pp. 301, (2018) (PubMed).

Qi, Xue, Lv, Sun, Du, Cai, Li, Gu, Wang: "Ginkgolic acids induce HepG2 cell death via a combination of apoptosis, autophagy and the mitochondrial pathway." in: Oncology letters, Vol. 15, Issue 5, pp. 6400-6408, (2018) (PubMed).

Shen, Cai, Liu, Li, Gan, Li, Wang, Guo, Zhou, Lu, Sun, Li: "Ube2v1-mediated ubiquitination and degradation of Sirt1 promotes metastasis of colorectal cancer by epigenetically suppressing autophagy." in: Journal of hematology & oncology, Vol. 11, Issue 1, pp. 95, (2018) (PubMed).

Wang, Ma, Hu, Xie, Wu, Zeng, Song: "Bifidobacterial recombinant thymidine kinase-ganciclovir gene therapy system induces FasL and TNFR2 mediated antitumor apoptosis in solid tumors." in: BMC cancer, Vol. 16, pp. 545, (2017) (PubMed).

Sun, Gao, Meng, Xu, Wang, Gu, Guo, Shao, Yan, Jiang, Zheng: "Antagomirs Targeting MiroRNA-134 Attenuates Epilepsy in Rats through Regulation of Oxidative Stress, Mitochondrial Functions and Autophagy." in: Frontiers in pharmacology, Vol. 8, pp. 524, (2017) (PubMed).

Bu, Zhao, Zhang, Wang, Li, Yan: "Recombinant Newcastle disease virus (rL-RVG) triggers autophagy and apoptosis in gastric carcinoma cells by inducing ER stress." in: American journal of cancer research, Vol. 6, Issue 5, pp. 924-36, (2016) (PubMed).
抗原

Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

别名

BECN1 (BECN1 产品)

别名

beclin-1 antibody, atg6 antibody, vps30 antibody, beclin1 antibody, Beclin-1 antibody, becn1 antibody, zgc:73097 antibody, ATG6 antibody, VPS30 antibody, 4921513J16Rik antibody, 5430417M23Rik antibody, Atg6 antibody, beclin 1 antibody, beclin 1, autophagy related antibody, beclin 1 protein antibody, beclin-1 antibody, beclin family protein antibody, beclin 1, autophagy related L homeolog antibody, BECN1 antibody, becn1 antibody, atg6 antibody, CpipJ_CPIJ011087 antibody, PTRG_07825 antibody, SJAG_01876 antibody, Becn1 antibody, becn1.L antibody

背景

Beclin-1, also known as also known as ATG6 or VPS30 is a protein that in humans is encoded by the BECN1 gene. Beclin-1 and its binding partner class III phosphoinositide 3-kinase (PI3K), also named Vps34, are required for the initiation of the formation of the autophagosome in autophagy. This gene participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. Schizophrenia is associated with low levels of Beclin-1 in the hippocampus of the affected which causes diminished autophagywhich in turn results in increased neuronal cell death. It has been found that beclin-1 can promote autophagy in autophagy-defective yeast with a targeted disruption of apg6/vps30, and in human MCF7 breast carcinoma cells.

Synonyms: APG6 antibody|ATG 6 antibody|ATG6 antibody|ATG6 autophagy related 6 homolog antibody|Bcl-2-interacting protein beclin antibody|Beclin 1 (coiled coil moesin like BCL2 interacting protein) antibody|Beclin 1 autophagy related antibody|Beclin-1 antibody|Beclin1 antibody|BECN 1 antibody|BECN1 antibody|BECN1_HUMAN antibody|Coiled coil myosin like BCL2 interacting protein antibody|Coiled-coil myosin-like BCL2-interacting protein antibody|GT197 antibody|Protein GT197 antibody|VPS 30 antibody|VPS30 antibody

基因ID

8678

UniProt

Q14457

途径

Autophagy

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