RRM2B 抗体 (C-Term)
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Quick Overview for RRM2B 抗体 (C-Term) (ABIN3032475)
抗原
See all RRM2B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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纯化方法
- Antigen affinity
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免疫原
- An amino acid sequence from the C-terminus of human p53 reductase small subunit 2 (EGKTNFFEKRVSEYQ) was used as the immunogen for this p53R2 antibody (100% homologous in human, mouse and rat).
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亚型
- IgG
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anti-Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B) (AA 3-84) antibody
RRM2B 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 6C1 unconjugated
anti-Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B) (AA 1-351) antibodyRRM2B 适用: 人 WB, ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B) (N-Term) antibodyRRM2B 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B) (AA 3-84) antibodyRRM2B 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6C1 unconjugated
anti-Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B) (N-Term) antibodyRRM2B 适用: 人 WB, ELISA, IHC, IP, FM 宿主: 兔 Polyclonal unconjugated
anti-Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B) (AA 2-17), (N-Term) antibodyRRM2B 适用: 人, 大鼠, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- The stated application concentrations are suggested starting amounts. Titration of the p53R2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL
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限制
- 仅限研究用
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- -20 °C
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储存方法
- After reconstitution, the p53R2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- RRM2B (Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B))
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别名
- p53R2
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背景
- Ribonucleotide Reductase, M2 B, also known as P53R2, is an enzyme that in humans is encoded by the RRM2B gene. Tanaka et al.(2000) mapped the gene to chromosome 8q23.1 by fluorescence in situ hybridization. Tanaka et al.(2000) found that expression of p53R2, but not R2, was induced by ultraviolet and gamma-irradiation and adriamycin treatment in a wildtype p53-dependent manner. Induction of p53R2 in p53-deficient cells caused G2/M arrest and protected cells from death in response to adriamycin. Inhibition of endogenous p53R2 expression in cells that had an intact p53-dependent DNA damage checkpoint reduced ribonucleotide reductase activity, DNA repair, and cell survival after exposure to various genotoxins.
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UniProt
- Q7LG56
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途径
- p53 Pathway, Negative Regulation of intrinsic apoptotic Signaling
抗原
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