An amino acid sequence from the C-terminus of mouse Aquaporin 0 (NGQPEGTGEPVELKTQAL) was used as the immunogen for this Aquaporin 0 antibody (100% rat homology).
MIP
适用: 人
IF (cc), IF (p)
宿主: 兔
Polyclonal
AbBy Fluor® 680
应用备注
The stated application concentrations are suggested starting amounts. Titration of the Aquaporin 0 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL
限制
仅限研究用
缓冲液
0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
储存条件
-20 °C
储存方法
After reconstitution, the Aquaporin 0 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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背景
Aquaporin 0, also called Lens fiber major intrinsic protein, MIP26 and MP26, is a protein that in humans is encoded by the MIP gene. It is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. Using 2-color fluorescence in situ hybridization on high-resolution R-banded chromosomes and human genomic DNA clones for MIP as probes, this gene was found that located in close proximity in region 12q13. MIP/Aquaporin 0 plays a crucial role in the development of a transparent eye lens. This gene may be responsible for regulating the osmolarity of the lens and interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core.