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GRIA2 抗体 (AA 25-360)

GRIA2 适用: 人, 大鼠, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3031067
发货至: 中国
  • 抗原 See all GRIA2 抗体
    GRIA2 (Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2))
    抗原表位
    • 29
    • 16
    • 7
    • 7
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 25-360
    适用
    • 93
    • 72
    • 67
    • 13
    • 11
    • 11
    • 6
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    人, 大鼠, 小鼠
    宿主
    • 91
    • 10
    克隆类型
    • 82
    • 19
    多克隆
    标记
    • 49
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This GRIA2 antibody is un-conjugated
    应用范围
    • 78
    • 27
    • 27
    • 24
    • 24
    • 16
    • 15
    • 8
    • 6
    • 6
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    纯化方法
    Antigen affinity
    免疫原
    Human partial recombinant protein (AA 25-360) was used as the immunogen for this GLUR2 antibody.
    亚型
    IgG
    Top Product
    Discover our top product GRIA2 Primary Antibody
  • 应用备注
    The stated application concentrations are suggested starting amounts. Titration of the GLUR2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL
    限制
    仅限研究用
  • 缓冲液
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    储存条件
    -20 °C
    储存方法
    After reconstitution, the GLUR2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Liu, Woo, Bukhari, Wang, Yan, Buosi, Ermekbaeva, Sista, Kotsiviras, LePochat, Chacko, Zhao, Kang: "Modulation of synaptic plasticity, motor unit physiology, and TDP-43 pathology by CHCHD10." in: Acta neuropathologica communications, Vol. 10, Issue 1, pp. 95, (2022) (PubMed).

  • 抗原
    GRIA2 (Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2))
    别名
    GLUR2 (GRIA2 产品)
    别名
    GLUR2 antibody, GLURB antibody, GluA2 antibody, GluR-K2 antibody, HBGR2 antibody, GluR-2 antibody, GluR-B antibody, Glur-2 antibody, Glur2 antibody, GluR2 antibody, gluR-B antibody, glur2a antibody, gria2.1 antibody, zfGRIA2[a] antibody, glur2 antibody, glutamate ionotropic receptor AMPA type subunit 2 antibody, glutamate receptor, ionotropic, AMPA 2 antibody, glutamate receptor, ionotropic, AMPA2 (alpha 2) antibody, glutamate receptor, ionotropic, AMPA 2a antibody, glutamate receptor, ionotropic, AMPA 2 S homeolog antibody, GRIA2 antibody, Gria2 antibody, gria2a antibody, gria2.S antibody
    背景
    Glutamate receptor 2, also known as GLUR2, is a protein that in humans is encoded by the GRIA2 gene. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. The crystal structures of the GLUR2 ligand-binding core in the apo state and in the presence of the antagonist DNQX, the partial agonist kainate, and the full agonists AMPA and glutamate. GLUR2 plays a major role in depression at synapses in which glutamate remains in the synaptic cleft for prolonged periods of time during normal operation of the synapse. Overexpression increases dendritic spine size and density in hippocampal neurons, and more remarkably, induces spine formation in GABA-releasing interneurons that normally lack spines.
    基因ID
    14800
    途径
    PI3K-Akt Signaling
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