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Desmoglein 3 抗体 (AA 981-999)

DSG3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3030722
发货至: 中国
  • 抗原 See all Desmoglein 3 (DSG3) 抗体
    Desmoglein 3 (DSG3)
    抗原表位
    • 15
    • 8
    • 7
    • 7
    • 7
    • 5
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 981-999
    适用
    • 69
    • 21
    • 16
    宿主
    • 62
    • 27
    克隆类型
    • 61
    • 28
    多克隆
    标记
    • 38
    • 9
    • 8
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Desmoglein 3 antibody is un-conjugated
    应用范围
    • 66
    • 36
    • 20
    • 18
    • 16
    • 13
    • 13
    • 8
    • 7
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB)
    纯化方法
    Antigen affinity
    免疫原
    Amino acids 981-999 (QLRGSHTMLCTEDPCSRLI-human ) were used as the immunogen for this Desmoglein 3 antibody.
    亚型
    IgG
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  • 应用备注
    The stated application concentrations are suggested starting amounts. Titration of the Desmoglein 3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL
    限制
    仅限研究用
  • 缓冲液
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    储存条件
    -20 °C
    储存方法
    After reconstitution, the Desmoglein 3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • 抗原
    Desmoglein 3 (DSG3)
    别名
    Desmoglein 3 (DSG3 产品)
    别名
    DSG3 antibody, CDHF6 antibody, PVA antibody, bal antibody, balding antibody, desmoglein 3 antibody, DSG3 antibody, Dsg3 antibody
    背景
    Desmoglein 3 is also known as PVA (Pemphigus Vulgaris Antigen). Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are autoimmune diseases of the skin which have as target antigens two different members of the desmoglein subfamily of the desmosomal cadherins: pemphigus vulgaris antigen (PVA, or Desmoglein 3) in the case of PV and Desmoglein 1 in the case of PF. The DSG3 gene, like the genes for DSG1 and DSG2, is located on chromosome 18. The human DSG3 gene consists of 15 exons and spans more than 23 kb. DSG3 and DSG1 are the autoantigens of pemphigus vulgaris and pemphigus foliaceus, respectively. DSG3 and DSG1 are the target antigens in PNP, and IgG autoantibodies against DSG3 in PNP sera play a pathogenic role in the loss of keratinocyte adhesion and blistering.
    UniProt
    P32926
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