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DLL3 抗体 (AA 599-618)

DLL3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3030711
发货至: 中国
  • 抗原 See all DLL3 抗体
    DLL3 (delta Like Protein 3 (DLL3))
    抗原表位
    • 11
    • 7
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 599-618
    适用
    • 60
    • 23
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    宿主
    • 58
    • 4
    克隆类型
    • 58
    • 4
    多克隆
    标记
    • 23
    • 6
    • 5
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This DLL3 antibody is un-conjugated
    应用范围
    • 50
    • 28
    • 23
    • 19
    • 11
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB)
    纯化方法
    Antigen affinity
    免疫原
    Amino acids 599-618 (RAGQRQHLLFPYPSSILSVK-human) were used as the immunogen for this DLL3 antibody.
    亚型
    IgG
    Top Product
    Discover our top product DLL3 Primary Antibody
  • 应用备注
    The stated application concentrations are suggested starting amounts. Titration of the DLL3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL
    限制
    仅限研究用
  • 缓冲液
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    储存条件
    -20 °C
    储存方法
    After reconstitution, the DLL3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • 抗原
    DLL3 (delta Like Protein 3 (DLL3))
    别名
    DLL3 (DLL3 产品)
    别名
    SCDO1 antibody, pu antibody, pudgy antibody, delta like canonical Notch ligand 3 antibody, delta-like 3 (Drosophila) antibody, DLL3 antibody, Dll3 antibody
    背景
    Delta-like 3 is a protein which in humans is encoded by the DLL3 gene. This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutation in the mouse delta-like 3 gene, which is homologous to the Notch-ligand delta in Drosophila, results in the mouse 'pudgy' phenotype. The human gene was identified within a critical interval, mapped in two consanguineous Arab-Israeli and Pakistani SCDO1 pedigrees, of 7.8 cM at 19q13.1-q13.3 between D19S570 and D19S908(Bulman et al., 2000). Dunwoodie et al.(1997) presented results suggesting that mouse DLL3 may complement the function of other delta homologs during early pattern formation in the mouse embryo. In humans, the fact that mutations in genes required for oscillation, such as DLL3, result in abnormal segmentation of the vertebral column suggests that the segmentation clock also acts during human embryonic development. This residue is highly conserved in Delta proteins from Drosophila to humans, and the substitution of a charged polar for a nonpolar residue may disrupt the conformation of the DLL3 protein.
    UniProt
    Q9NYJ7
    途径
    Notch Signaling
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