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TICAM1 抗体 (C-Term)

TICAM1 适用: 人 WB, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3029185
发货至: 中国
  • 抗原 See all TICAM1 抗体
    TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))
    抗原表位
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    适用
    • 24
    • 9
    • 3
    • 2
    宿主
    • 22
    • 3
    • 3
    克隆类型
    • 25
    • 3
    多克隆
    标记
    • 21
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TICAM1 antibody is un-conjugated
    应用范围
    • 20
    • 7
    • 7
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    纯化方法
    Antigen affinity
    免疫原
    An amino acid sequence from the C-terminus of human TRIF (NNHMWNQRGSQAPEDKTQEAE) was used as the immunogen for this TRIF antibody.
    亚型
    Ig Fraction
    Top Product
    Discover our top product TICAM1 Primary Antibody
  • 应用备注
    The stated application concentrations are suggested starting points. Titration of the TRIF antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,IHC (Frozen): 0.5-1 μg/mL
    限制
    仅限研究用
  • 缓冲液
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    储存条件
    -20 °C
    储存方法
    After reconstitution, the TRIF antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • 抗原
    TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))
    别名
    TRIF (TICAM1 产品)
    别名
    IIAE6 antibody, MyD88-3 antibody, PRVTIRB antibody, TICAM-1 antibody, TRIF antibody, AW046014 antibody, AW547018 antibody, trif antibody, toll like receptor adaptor molecule 1 antibody, toll-like receptor adaptor molecule 1 antibody, TICAM1 antibody, Ticam1 antibody, ticam1 antibody
    背景
    TIR Domain-containing adaptor molecule 1, also known as TICAM1 or TRIF, is an adapter in responding to activation of toll-like receptors (TLRs). It mediates the delayed cascade of two TLR-associated signaling cascades, where the other one is dependent upon a MyD88 adapter. By genomic sequence analysis, Oshiumi et al.(2003) mapped the gene to chromosome 19p13.3. By coimmunoprecipitation analysis, Oshiumi et al.(2003) showed that the protein interacts specifically with < a href=../search_result.php?search_txt=TLR3>TLR3, but not with other TLRs. Functional analysis showed that the association of TLR3 and TRIF mediates dsRNA activation of IFNB, through either < a href=../search_result.php?search_txt=nfkb>NFKB, < a href=../search_result.php?search_txt=ap1>AP1, or < a href=../search_result.php?search_txt=irf3>IRF3. TRIF activation of NFKB was found to occur predominantly through < a href=../search_result.php?search_txt=irak1>IRAK1 rather than < a href=../search_result.php?search_txt=irak2>IRAK2. siRNA blockage of the protein reduced IFNB production in response to dsRNA.
    UniProt
    Q8IUC6
    途径
    TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades
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