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Transglutaminase 2 抗体

TGM2 适用: 人, 小鼠, 大鼠, 猴, 兔 IF, IHC (p), FACS 宿主: 小鼠 Monoclonal TGM2-419 unconjugated
产品编号 ABIN3025598
发货至: 中国
  • 抗原 See all Transglutaminase 2 (TGM2) 抗体
    Transglutaminase 2 (TGM2) (Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM2))
    适用
    • 115
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    人, 小鼠, 大鼠, 猴, 兔
    宿主
    • 96
    • 33
    • 3
    • 1
    小鼠
    克隆类型
    • 93
    • 40
    单克隆
    标记
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    This Transglutaminase 2 antibody is un-conjugated
    应用范围
    • 89
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    Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)
    纯化方法
    Protein G affinity chromatography
    免疫原
    Recombinant full-length human protein was used as the immunogen for the Transglutaminase 2 antibody.
    克隆位点
    TGM2-419
    亚型
    IgG2a kappa
    Top Product
    Discover our top product TGM2 Primary Antibody
  • 应用备注
    Optimal dilution of the Transglutaminase 2 antibody should be determined by the researcher.

    1. Staining of formalin-fixed tissues requires boiling tissue sections in 10  mM Citrate buffer,  pH 6.0, for 10-20 min followed by cooling at RT for 20 min.
    2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Flow Cytometry: 0.5-1 μg/million cells in 0.1ml,Immunofluorescence: 0.5-1 μg/mL,Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT (1),Prediluted format: incubate for 30 min at RT (2)

    限制
    仅限研究用
  • 浓度
    1 mg/mL
    缓冲液
    1 mg/mL in 1X PBS, BSA free, sodium azide free
    储存液
    Azide free
    储存条件
    4 °C,-20 °C
    储存方法
    Store the Transglutaminase 2 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
  • 抗原
    Transglutaminase 2 (TGM2) (Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM2))
    别名
    Transglutaminase 2 (TGM2 产品)
    别名
    G-ALPHA-h antibody, GNAH antibody, TG2 antibody, TGC antibody, tgm2 antibody, zgc:101081 antibody, TgaseII antibody, TGM2 antibody, fc12b04 antibody, wu:fc12b04 antibody, zgc:136700 antibody, TGL2 antibody, G[a]h antibody, TGase2 antibody, tTG antibody, tTGas antibody, transglutaminase 2 antibody, transglutaminase 2, C polypeptide A antibody, transglutaminase 2b antibody, transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) antibody, transglutaminase 2, C polypeptide antibody, TGM2 antibody, tgm2a antibody, Tgm2 antibody, tgm2b antibody
    背景
    Recognizes a 77-85  kDa protein, identified as cellular or tissue transglutaminase II (TGase II). Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. The identification of transglutaminase as the main antigen of endomysium antibodies allows a new diagnostic approach to celiac disease (CD), a genetic, immunologically mediated small bowel enteropathy that causes malabsorption. TGase II is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing.
    途径
    Tube Formation, Thromboxane A2 Receptor Signaling
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