The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis.,THBS1,THBS,THBS-1,TSP,TSP-1,TSP1,Cancer,Invasion and Metastasis,Cell Biology & Developmental Biology,Cell Adhesion,Endocrine & Metabolism,Neuroscience,Cell Type Marker,Stem Cells,Cardiovascular,Angiogenesis,Angiogenic inhibitory factors,Blood,Hypoxia,Astrocyte marker,THBS1