The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.,CD247,CD3-ZETA,CD3H,CD3Q,CD3Z,IMD25,T3Z,TCRZ,Immunology & Inflammation,CD markers,T Cell Receptor Signaling Pathway,CD247