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Macrophage Scavenger Receptor 1 抗体 (AA 192-451)

MSR1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3022664
发货至: 中国
  • 抗原 See all Macrophage Scavenger Receptor 1 (MSR1) 抗体
    Macrophage Scavenger Receptor 1 (MSR1)
    抗原表位
    • 16
    • 8
    • 7
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 192-451
    适用
    • 57
    • 55
    • 16
    • 16
    • 8
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    宿主
    • 56
    • 16
    • 4
    克隆类型
    • 55
    • 17
    多克隆
    标记
    • 29
    • 8
    • 6
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Macrophage Scavenger Receptor 1 antibody is un-conjugated
    应用范围
    • 57
    • 34
    • 29
    • 13
    • 13
    • 12
    • 11
    • 9
    • 8
    • 5
    • 4
    • 4
    • 2
    Western Blotting (WB)
    序列
    LNIENLNGKI QENTFKQQEE ISKLEERVYN VSAEIMAMKE EQVHLEQEIK GEVKVLNNIT NDLRLKDWEH SQTLRNITLI QGPPGPPGEK GDRGPTGESG PRGFPGPIGP PGLKGDRGAI GFPGSRGLPG YAGRPGNSGP KGQKGEKGSG NTLTPFTKVR LVGGSGPHEG RVEILHSGQW GTICDDRWEV RVGQVVCRSL GYPGVQAVHK AAHFGQGTGP IWLNEVFCFG RESSIEECKI RQWGTRACSH SEDAGVTCTL
    交叉反应
    人, 小鼠, 大鼠
    产品特性
    Polyclonal Antibodies
    免疫原
    Recombinant fusion protein containing a sequence corresponding to amino acids 192-451 of human MSR1 (NP_619729.1).
    亚型
    IgG
    Top Product
    Discover our top product MSR1 Primary Antibody
  • 应用备注
    WB,1:500 - 1:2000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid freeze / thaw cycles
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    Macrophage Scavenger Receptor 1 (MSR1)
    别名
    MSR1 (MSR1 产品)
    别名
    CD204 antibody, SCARA1 antibody, SR-A antibody, SRA antibody, phSR1 antibody, phSR2 antibody, MRS-A antibody, MSR antibody, MSR-A antibody, SR-AI antibody, SR-AII antibody, Scara1 antibody, Scvr antibody, MSR1 antibody, RGD1564316 antibody, macrophage scavenger receptor 1 antibody, scavenger receptor class A member 5 antibody, MSR1 antibody, Msr1 antibody, SCARA5 antibody
    背景
    This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.,MSR1,CD204,SCARA1,SR-A,SR-AI,SR-AII,SR-AIII,SRA,phSR1,phSR2,Cancer,Endocrine & Metabolism,Lipid Metabolism,Immunology & Inflammation,CD markers,Cell Intrinsic Innate Immunity Signaling Pathway,Cardiovascular,Heart,Cardiovascular diseases,Heart disease,MSR1
    分子量
    39 kDa/42 kDa/49 kDa
    基因ID
    4481
    UniProt
    P21757
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