HMGCR 抗体 (AA 629-888)
(2 references)-
- 抗原 See all HMGCR 抗体
- HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))
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抗原表位
- AA 629-888
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This HMGCR antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- 序列
- ARLQKLHTSI AGRNLYIRFQ SRSGDAMGMN MISKGTEKAL SKLHEYFPEM QILAVSGNYC TDKKPAAINW IEGRGKSVVC EAVIPAKVVR EVLKTTTEAM IEVNINKNLV GSAMAGSIGG YNAHAANIVT AIYIACGQDA AQNVGSSNCI TLMEASGPTN EDLYISCTMP SIEIGTVGGG TNLLPQQACL QMLGVQGACK DNPGENARQL ARIVCGTVMA GELSLMAALA AGHLVKSHMI HNRSKINLQD LQGACTKKTA
- 交叉反应
- 人, 小鼠, 大鼠
- 产品特性
- Polyclonal Antibodies
- 纯化方法
- Affinity purification
- 免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 629-888 of human HMGCR (NP_000850.1).
- 亚型
- IgG
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anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (AA 638-887) antibody
HMGCR 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (pSer872) antibodyHMGCR 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (AA 588-887) antibodyHMGCR 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (N-Term) antibodyHMGCR 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (AA 251-350) antibodyHMGCR 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (Internal Region) antibodyVerified HMGCR 适用: 人 ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (AA 1-835) antibodyHMGCR 适用: 人 IP 宿主: 兔 Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) antibodyHMGCR 适用: 人, 大鼠, 小鼠 WB, IF, IC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB,1:1000 - 1:4000,IHC,1:50 - 1:100,IF,1:50 - 1:200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid freeze / thaw cycles
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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: "MicroRNA-148a deficiency promotes hepatic lipid metabolism and hepatocarcinogenesis in mice." in: Cell death & disease, Vol. 8, Issue 7, pp. e2916, (2018) (PubMed).
: "Effects of sepsis on the metabolism of sphingomyelin and cholesterol in mice with liver dysfunction." in: Experimental and therapeutic medicine, Vol. 14, Issue 6, pp. 5635-5640, (2017) (PubMed).
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: "MicroRNA-148a deficiency promotes hepatic lipid metabolism and hepatocarcinogenesis in mice." in: Cell death & disease, Vol. 8, Issue 7, pp. e2916, (2018) (PubMed).
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- 抗原
- HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))
- 别名
- HMGCR (HMGCR 产品)
- 别名
- HMGR antibody, LDLCQ3 antibody, hmg-coa-r antibody, HMG-CoAR antibody, Red antibody, 3H3M antibody, BcDNA:LD15354 antibody, CG10367 antibody, Clb antibody, DmHMG-CoAr antibody, Dmel\\CG10367 antibody, HMGCR antibody, HMGCR_Dm antibody, HMGCoAR antibody, HMGCoARr antibody, HMGCoAr antibody, HmG-CoAR antibody, Hmg antibody, bro1 antibody, bs32f05.y1 antibody, clb antibody, hmgc antibody, hmgcr antibody, hmgrc antibody, l(3)01152 antibody, l(3)04684 antibody, hmgcr2 antibody, im:6912716 antibody, zgc:110746 antibody, 3-hydroxy-3-methylglutaryl-CoA reductase antibody, 3-hydroxy-3-methylglutaryl-CoA reductase L homeolog antibody, 3-hydroxy-3-methylglutaryl-Coenzyme A reductase antibody, HMG Coenzyme A reductase antibody, 3-hydroxy-3-methylglutaryl-CoA reductase b antibody, HMGCR antibody, hmgcr.L antibody, Hmgcr antibody, hmgcrb antibody
- 背景
- HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.,HMGCR,LDLCQ3,HMGCR,Cancer,Signal Transduction,Endocrine & Metabolism,Lipid Metabolism,Cholesterol Metabolism,AMPK Signaling Pathway,Cardiovascular,Heart,Lipids,Cardiovascular diseases,Heart disease,HMGCR
- 分子量
- 92 kDa/97 kDa/99 kDa
- 基因ID
- 3156
- UniProt
- P04035
- 途径
- AMPK Signaling, Negative Regulation of Hormone Secretion, Regulation of Lipid Metabolism by PPARalpha
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