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Cyclin D1 抗体 (C-Term)

Name: Cyclin D1 抗体 (C-Term)
Brand: antibodies-online
SKU: ABIN3021887
Availability: OutOfStock

CCND1 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated

Western blot analysis of extracts of various cell lines, using Cyclin D1 antibody at 1:1000 dilution. (Cyclin D1 抗体 (C-Term))

Immunoprecipitation analysis of 200 μg extracts of HepG2 cells, using 3 μg Cyclin D1 antibody . (Cyclin D1 抗体 (C-Term))

Western blot analysis of extracts from normal (control) and Cyclin D1 knockout (KO) HeLa cells, using Cyclin D1 antibody at 1:1000 dilution. (Cyclin D1 抗体 (C-Term))

3 images

(6 references)

产品编号 ABIN3021887

发货至: 中国

Datasheet as PDF

抗原 See all Cyclin D1 (CCND1) 抗体

Cyclin D1 (CCND1)
抗原表位
21

16

16

13

12

9

9

8

7

6

4

4

3

3

3

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
C-Term
适用
208

115

109

40

20

18

16

12

9

8

3

3

3

3

3

2

2

1

1

1

1
人
宿主
176

54

1
兔
Compatible Secondaries
克隆类型
164

65
多克隆
标记
116

21

17

7

5

3

3

3

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1
This Cyclin D1 antibody is un-conjugated
应用范围
181

73

62

60

38

29

28

27

25

20

19

11

6

5

3

2

2

2

1

1

1
Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

序列

PSMVAAGSVV AAVQGLNLRS PNNFLSYYRL TRFLSRVIKC DPDCLRACQE QIEALLESSL RQAQQNMDPK AAEEEEEEEE EVDLACTPTD VRDVDI

交叉反应

人, 小鼠, 大鼠

产品特性

Polyclonal Antibodies

纯化方法

Affinity purification

免疫原

A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human Cyclin D1 (NP_444284.1).

亚型

IgG

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CCND1 适用: 人, 小鼠, 大鼠, Cow, 兔, 绵羊 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Cyclin D1 (CCND1) (C-Term) antibody
CCND1 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated

anti-Cyclin D1 (CCND1) antibody
KO Validated CCND1 适用: 人 WB, IHC, IF, IP 宿主: 兔 Monoclonal unconjugated

anti-Cyclin D1 (CCND1) (AA 1-295) antibody
CCND1 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 1F7F5 unconjugated

anti-Cyclin D1 (CCND1) (AA 167-295) antibody
CCND1 适用: 人 ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 3B6G3 unconjugated

anti-Cyclin D1 (CCND1) (C-Term) antibody
CCND1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Cyclin D1 (CCND1) (AA 68-97) antibody
CCND1 适用: 人, 小鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB8066 unconjugated

anti-Cyclin D1 (CCND1) (AA 68-97) antibody
CCND1 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Cyclin D1 (CCND1) antibody
CCND1 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, FACS, IF, StM 宿主: 小鼠 Monoclonal DCS-6 unconjugated

anti-Cyclin D1 (CCND1) (AA 1-233) antibody
CCND1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

应用备注

WB,1:500 - 1:2000,IF,1:50 - 1:200,IP,1:50 - 1:100

限制

仅限研究用
状态

Liquid

缓冲液

PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid freeze / thaw cycles

储存条件

-20 °C

储存方法

Store at -20°C. Avoid freeze / thaw cycles.
Wu, Xiong, Li, Yang, Ge et al.: "Integrated Proteomic and Transcriptomic Analysis Reveals Long Noncoding RNA HOX Transcript Antisense Intergenic RNA (HOTAIR) Promotes Hepatocellular Carcinoma Cell Proliferation by Regulating Opioid ..." in: Molecular & cellular proteomics : MCP, Vol. 17, Issue 1, pp. 146-159, (2019) (PubMed).

Deng, Wang, Zhao, Zhang, Chen, Zhao, Liu, Sun, Zhang, Ye, Du: "MICAL1 facilitates breast cancer cell proliferation via ROS-sensitive ERK/cyclin D pathway." in: Journal of cellular and molecular medicine, Vol. 22, Issue 6, pp. 3108-3118, (2018) (PubMed).

Wang, Huang, Zhang, Hou, Liu, Chen, Zhu, Zhang: "Toosendanin suppresses oncogenic phenotypes of human gastric carcinoma SGC‑7901 cells partly via miR‑200a‑mediated downregulation of β-catenin pathway." in: International journal of oncology, Vol. 51, Issue 5, pp. 1563-1573, (2018) (PubMed).

Li, Kang, Yin, Li, Chen, Li, Zhang, Qiu: "Ginsenoside Rh2 inhibits human A172 glioma cell proliferation and induces cell cycle arrest status via modulating Akt signaling pathway." in: Molecular medicine reports, Vol. 17, Issue 2, pp. 3062-3068, (2018) (PubMed).

Li, Lv, He, Wang, Zhang, Lu, Ren, Wang, Zhu, Ding, Liao, Ding, Liang: "The SOX17/miR-371-5p/SOX2 axis inhibits EMT, stem cell properties and metastasis in colorectal cancer." in: Oncotarget, Vol. 6, Issue 11, pp. 9099-112, (2016) (PubMed).

Gao, Wang, Zhao, Chen, Xie: "MicroRNA-204-5p-Mediated Regulation of SIRT1 Contributes to the Delay of Epithelial Cell Cycle Traversal in Diabetic Corneas." in: Investigative ophthalmology & visual science, Vol. 56, Issue 3, pp. 1493-504, (2015) (PubMed).
抗原

Cyclin D1 (CCND1)

别名

CCND1 (CCND1 产品)

背景

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.,BCL1,D11S287E,PRAD1,U21B31,CCND1,Cyclin D1,cyclin D1,Epigenetics & Nuclear Signaling,Cancer,Signal Transduction,PI3K-Akt Signaling Pathway,Cell Biology & Developmental Biology,Cell Cycle,Cyclins,G1/S Checkpoint,Hedgehog Signaling Pathway,CCND1

分子量

33 kDa

基因ID

595

UniProt

P24385

途径

PI3K-Akt Signaling, Cell Division Cycle, Mitotic G1-G1/S Phases, ER-Nucleus Signaling