Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1.,NUAK2,SNARK,Cancer,Invasion and Metastasis,Signal Transduction,Kinase,Cell Biology & Developmental Biology,Apoptosis,Cytoskeleton,Microfilaments,NUAK2