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p53 抗体 (AA 1-110)

Name: p53 抗体 (AA 1-110)
Brand: antibodies-online
SKU: ABIN3020823
Availability: OutOfStock

TP53 适用: 人 WB, IHC, IF, IP, ChIP 宿主: 兔 Polyclonal unconjugated

Western blot analysis of extracts of various cell lines, using TP53 antibody. (p53 抗体 (AA 1-110))

Immunofluorescence analysis of A549 cells using TP53 antibody. (p53 抗体 (AA 1-110))

2 images

(4 references)

产品编号 ABIN3020823

发货至: 中国

Datasheet as PDF

抗原 See all p53 (TP53) 抗体

p53 (TP53) (Tumor Protein P53 (TP53))
抗原表位
43

40

37

30

29

29

26

26

24

22

20

20

19

19

18

18

16

15

13

9

8

8

8

7

7

6

6

6

6

6

6

6

5

5

4

4

4

4

4

4

4

4

4

4

3

3

3

3

3

3
AA 1-110
适用
823

252

208

104

47

33

31

18

10

9

7

6

6

3

3

3

2

2

2

2

2

1

1

1
人
宿主
622

218

6

2

1
兔
Compatible Secondaries
克隆类型
558

290

1
多克隆
标记
476

38

31

19

18

13

13

13

13

13

13

13

13

13

12

11

11

11

11

11

11

11

11

5

5

5

5

5

5

2

2

2

2

2

2

2

1

1

1

1

1

1
This p53 antibody is un-conjugated
应用范围
661

298

247

199

198

148

124

121

119

64

59

32

18

16

13

12

9

8

8

6

4

3

3

2

2

2

1

1

1

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Chromatin Immunoprecipitation (ChIP)

序列

MEEPQSDPSV EPPLSQETFS DLWKLLPENN VLSPLPSQAM DDLMLSPDDI EQWFTEDPGP DEAPRMPEAA PPVAPAPAAP TPAAPAPAPS WPLSSSVPSQ KTYQGSYGFR

交叉反应

人, 小鼠, 大鼠

产品特性

Polyclonal Antibodies

纯化方法

Affinity purification

免疫原

Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human p53 (NP_000537.3).

亚型

IgG

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TP53 适用: 人 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated

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TP53 适用: 人 WB, IF, IHC (p), IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Tumor Protein P53 (TP53) (AA 301-393) antibody
TP53 适用: 人, 小鼠, 大鼠, 山羊 WB, ELISA, FACS, IHC (p), ICC, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

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TP53 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

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TP53 适用: 人 WB, ELISA, IF, IHC (p), IP 宿主: 小鼠 Monoclonal 2C3 unconjugated

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TP53 适用: 人 WB, ELISA, IHC (p), PLA, RNAi 宿主: 小鼠 Monoclonal 2C11 unconjugated

anti-Tumor Protein P53 (TP53) (acLys319) antibody
TP53 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Tumor Protein P53 (TP53) (pSer20) antibody
TP53 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200,ChIP,1:50 - 1:100,IP,1:50 - 1:200

限制

仅限研究用
状态

Liquid

缓冲液

PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid freeze / thaw cycles

储存条件

-20 °C

储存方法

Store at -20°C. Avoid freeze / thaw cycles.
Feng, Yu, Liu, Zhang, Cheng, Li, Tan, Luo, Jiang: "KAT5 silencing induces apoptosis of GBC-SD cells through p38MAPK-mediated upregulation of cleaved Casp9." in: International journal of clinical and experimental pathology, Vol. 7, Issue 1, pp. 80-91, (2014) (PubMed).

Zhu, Wang, Yang, Guo, Li, Wang, Wang, Huang, Wang, Yang, Ma, Bi: "Comparison of toxicity of benzene metabolite hydroquinone in hematopoietic stem cells derived from murine embryonic yolk sac and adult bone marrow." in: PLoS ONE, Vol. 8, Issue 8, pp. e71153, (2013) (PubMed).

He, Zhang, Wang, Zhong, Shao, Zhu, Shen: "AURKA suppression induces DU145 apoptosis and sensitizes DU145 to docetaxel treatment." in: American journal of translational research, Vol. 5, Issue 3, pp. 359-67, (2013) (PubMed).

Bao, Lu, Bin, Chang, Meng, Zhou, Guo, Zhao: "Systematic screen with kinases inhibitors reveals kinases play distinct roles in growth of osteoprogenitor cells." in: International journal of clinical and experimental pathology, Vol. 6, Issue 10, pp. 2082-91, (2013) (PubMed).
抗原

p53 (TP53) (Tumor Protein P53 (TP53))

别名

TP53 (TP53 产品)

背景

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).,BCC7,LFS1,P53,TRP53,p53,TP53,BMFS5,Epigenetics & Nuclear Signaling,Transcription Factors,DNA Damage & Repair,Cancer,Tumor suppressors,p53 pathway,Signal Transduction,PI3K-Akt Signaling Pathway,ErbB-HER Signaling Pathway,MAPK-JNK Signaling Pathway,MAPK-P38 Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Mitochondrial Control of Apoptosis,Cell Cycle,Cell cycle inhibitors,G1/S Checkpoint,G2/M DNA Damage Checkpoint,Endocrine & Metabolism,AMPK Signaling Pathway,Warburg Effect,Neuroscience,Neurodegenerative Diseases,TP53

分子量

23-43 kDa

基因ID

7157

UniProt

P04637

途径

p53 Pathway, MAPK Pathway, PI3K-Akt Signaling, Apoptosis, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy, Warburg Effect