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Lamin A/C 抗体 (AA 403-572)

Name: Lamin A/C 抗体 (AA 403-572)
Brand: antibodies-online
SKU: ABIN3020785
Availability: OutOfStock

LMNA 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated

Western blot analysis of extracts of various cell lines, using LMNA antibody. (Lamin A/C 抗体 (AA 403-572))

Immunohistochemistry (IHC) image for anti-Lamin A/C (LMNA) (AA 403-572) antibody (ABIN3020785) (Lamin A/C 抗体 (AA 403-572))

IHC

Immunohistochemistry of paraffin-embedded mouse brain using LMNA antibody at dilution of 1:200 (x400 lens). (Lamin A/C 抗体 (AA 403-572))

IHC

Immunohistochemistry of paraffin-embedded Human gastric using LMNA antibody at dilution of 1:100 (x400 lens). (Lamin A/C 抗体 (AA 403-572))

32 images

(11 references)

产品编号 ABIN3020785

发货至: 中国

Datasheet as PDF

抗原 See all Lamin A/C (LMNA) 抗体

Lamin A/C (LMNA)
抗原表位
11

8

8

8

7

7

7

6

5

4

4

4

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 403-572
适用
143

83

80

27

15

13

8

7

6

6

6

4

4

3

3

2

2

1

1

1

1

1

1
人
宿主
109

45

2

1
兔
Compatible Secondaries
克隆类型
111

46
多克隆
标记
114

10

9

8

3

3

2

2

1

1

1

1

1

1
This Lamin A/C antibody is un-conjugated
应用范围
126

59

55

45

30

29

28

20

14

7

3

2

2

1

1
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

序列

SSHSSQTQGG GSVTKKRKLE STESRSSFSQ HARTSGRVAV EEVDEEGKFV RLRNKSNEDQ SMGNWQIKRQ NGDDPLLTYR FPPKFTLKAG QVVTIWAAGA GATHSPPTDL VWKAQNTWGC GNSLRTALIN STGEEVAMRK LVRSVTVVED DEDEDGDDLL HHHHVSGSRR

交叉反应

人, 小鼠, 大鼠

产品特性

Polyclonal Antibodies

免疫原

Recombinant fusion protein containing a sequence corresponding to amino acids 403-572 of human Lamin C (NP_005563.1).

亚型

IgG
anti-Lamin A/C (LMNA) antibody
KO Validated LMNA 适用: 人 WB, IF, IP, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Lamin A/C (LMNA) (pSer392) antibody
LMNA 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Lamin A/C (LMNA) antibody
KO Validated LMNA 适用: 人 WB, IHC, IF, IP 宿主: 兔 Monoclonal unconjugated

anti-Lamin A/C (LMNA) antibody
LMNA 适用: 人 IHC, ELISA, IF, IP, FACS 宿主: 兔 Monoclonal 4H7 unconjugated Recombinant Antibody

anti-Lamin A/C (LMNA) antibody
LMNA 适用: 人 WB, IHC, ELISA 宿主: 小鼠 Monoclonal 4E7 unconjugated

anti-Lamin A/C (LMNA) (AA 481-646) antibody
LMNA 适用: 人, 小鼠, 大鼠 WB, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Lamin A/C (LMNA) (AA 455-469) antibody
LMNA 适用: 人, 小鼠, 大鼠 WB, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Lamin A/C (LMNA) antibody
LMNA 适用: 人, 小鼠, 大鼠, Cow, 犬 WB, IHC, ICC, FACS, IHC (fro) 宿主: 小鼠 Monoclonal 133A2 unconjugated

anti-Lamin A/C (LMNA) (C-Term) antibody
LMNA 适用: 人, 小鼠, 大鼠, Cow, Pig, 犬, 猴, 马, 兔, Hamster, 小鸡, 绵羊, 豚鼠, 山羊, Avian, Cat, 驴 WB 宿主: 山羊 Polyclonal unconjugated

anti-Lamin A/C (LMNA) (AA 1-664) antibody
LMNA 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated

应用备注

WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200,IP,1:50 - 1:200

限制

仅限研究用
状态

Liquid

缓冲液

PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid freeze / thaw cycles

储存条件

-20 °C

储存方法

Store at -20°C. Avoid freeze / thaw cycles.
Wei, Dai, Zhou, He, Yao, Zhao, Guo, Yang: "Oroxylin A activates PKM1/HNF4 alpha to induce hepatoma differentiation and block cancer progression." in: Cell death & disease, Vol. 8, Issue 7, pp. e2944, (2018) (PubMed).

Wan, Ashraf, Ye, Duan, Zohaib, Wang, Chen, Zhu, Li, Chen, Cao: "MicroRNA-22 negatively regulates poly(I:C)-triggered type I interferon and inflammatory cytokine production via targeting mitochondrial antiviral signaling protein (MAVS)." in: Oncotarget, Vol. 7, Issue 47, pp. 76667-76683, (2018) (PubMed).

He, Zhao, Anees, Li, Ashraf, Chen, Song, Chen, Cao, Ye: "p21-Activated Kinase 4 Signaling Promotes Japanese Encephalitis Virus-Mediated Inflammation in Astrocytes." in: Frontiers in cellular and infection microbiology, Vol. 7, pp. 271, (2018) (PubMed).

Shang, Xia, Han, Zhao, Hu, Shu, Guo: "Quantitative Proteomics Identified TTC4 as a TBK1 Interactor and a Positive Regulator of SeV-Induced Innate Immunity." in: Proteomics, Vol. 18, Issue 2, (2018) (PubMed).

Ye, Chen, Li, Zhao, He, Zohaib, Song, Deng, Zhang, Chen, Cao: "Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-κB." in: Journal of virology, Vol. 91, Issue 8, (2017) (PubMed).

Zhu, Ye, Ashraf, Li, Chen, Song, Cao: "Transcriptional regulation of miR-15b by c-Rel and CREB in Japanese encephalitis virus infection." in: Scientific reports, Vol. 6, pp. 22581, (2017) (PubMed).

Ashraf, Zhu, Ye, Wan, Nie, Chen, Cui, Wang, Duan, Zhang, Chen, Cao: "MicroRNA-19b-3p Modulates Japanese Encephalitis Virus-Mediated Inflammation via Targeting RNF11." in: Journal of virology, Vol. 90, Issue 9, pp. 4780-4795, (2016) (PubMed).

Zhang, Sun, Ye, Ashraf, Chen, Zhu, He, Xu, Wei, Chen, Fu, Liu, Cao: "Quantitative Label-Free Phosphoproteomics Reveals Differentially Regulated Protein Phosphorylation Involved in West Nile Virus-Induced Host Inflammatory Response." in: Journal of proteome research, Vol. 14, Issue 12, pp. 5157-68, (2016) (PubMed).

Zhu, Ye, Nie, Ashraf, Zohaib, Duan, Fu, Song, Chen, Cao: "MicroRNA-15b Modulates Japanese Encephalitis Virus-Mediated Inflammation via Targeting RNF125." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 195, Issue 5, pp. 2251-62, (2015) (PubMed).

Duan, Zohaib, Li, Zhu, Ye, Wan, Xu, Song, Chen, Cao: "miR-206 modulates lipopolysaccharide-mediated inflammatory cytokine production in human astrocytes." in: Cellular signalling, Vol. 27, Issue 1, pp. 61-8, (2015) (PubMed).

Ye, Jiang, Cui, Zhu, Sun, Wang, Zohaib, Dong, Ruan, Song, He, Chen, Cao: "Etanercept reduces neuroinflammation and lethality in mouse model of Japanese encephalitis." in: The Journal of infectious diseases, Vol. 210, Issue 6, pp. 875-89, (2014) (PubMed).
抗原

Lamin A/C (LMNA)

别名

LMNA (LMNA 产品)

别名

CDCD1 antibody, CDDC antibody, CMD1A antibody, CMT2B1 antibody, EMD2 antibody, FPL antibody, FPLD antibody, FPLD2 antibody, HGPS antibody, IDC antibody, LDP1 antibody, LFP antibody, LGMD1B antibody, LMN1 antibody, LMNC antibody, LMNL1 antibody, PRO1 antibody, Dhe antibody, 2459 antibody, 74/76 antibody, CG6944 antibody, D5 antibody, DM[[O]] antibody, Dm antibody, Dm(0) antibody, Dm0 antibody, Dm1 antibody, Dm2 antibody, DmLamin antibody, DmO antibody, Dm[[0]] antibody, Dm[[1]] antibody, Dm[[2]] antibody, Dm[[mit]] antibody, Dm[[o]] antibody, Dmel\\CG6944 antibody, Dmo antibody, LAM antibody, Lam Dm[[0]] antibody, Lam(Dm0) antibody, LamDm[[0]] antibody, LamDm[[o]] antibody, Lam[[Dm0]] antibody, Lamin Dm[[0]] antibody, jf27 antibody, l(2)04643 antibody, l(2)25Ec antibody, l(2)gdh-7 antibody, l(2)gdh7 antibody, l(2)jf27 antibody, lam antibody, lamDm0 antibody, lamDm[[0]] antibody, lamin antibody, lamin Dm0 antibody, lamin Dm[[0]] antibody, misg antibody, nlam antibody, cb948 antibody, fk66d12 antibody, wu:fk66d12 antibody, lmna-A antibody, fpl antibody, idc antibody, lfp antibody, cddc antibody, emd2 antibody, fpld antibody, hgps antibody, ldp1 antibody, lmn1 antibody, lmnc antibody, pro1 antibody, cdcd1 antibody, cmd1a antibody, cmt2b1 antibody, lgmd1b antibody, Lamin-A antibody, lamin-L(III)-like antibody, lamin A/C antibody, lamin A antibody, Lamin antibody, lamin A/C L homeolog antibody, lamin-L(III)-like antibody, LMNA antibody, Lmna antibody, Lam antibody, lmna antibody, lmna.L antibody, LMINA antibody

背景

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.,LMNA,CDCD1,CDDC,CMD1A,CMT2B1,EMD2,FPL,FPLD,FPLD2,HGPS,IDC,LDP1,LFP,LGMD1B,LMN1,LMNC,LMNL1,MADA,PRO1,lamin,Lamin A/C,Signal Transduction,PI3K-Akt Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Cell Cycle,Cytoskeleton,Intermediate Filaments,Protein folding,Death Receptor Signaling Pathway,Stem Cells,LMNA

分子量

62-74 kDa

基因ID

4000

UniProt

P02545

途径

Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus