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- 抗原 See all ERK2 (MAPK1) 抗体
- ERK2 (MAPK1) (Mitogen-Activated Protein Kinase 1 (MAPK1))
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抗原表位
- AA 200-300
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ERK2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 序列
- LNSKGYTKSI DIWSVGCILA EMLSNRPIFP GKHYLDQLNH ILGILGSPSQ EDLNCIINLK ARNYLLSLPH KNKVPWNRLF PNADSKALDL LDKMLTFNPH K
- 交叉反应
- 人, 小鼠, 大鼠
- 产品特性
- Polyclonal Antibodies
- 免疫原
- A synthetic peptide corresponding to a sequence within amino acids 200-300 of human ERK2 (NP_620407.1).
- 亚型
- IgG
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- 应用备注
- WB,1:500 - 1:2000,IF,1:50 - 1:200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid freeze / thaw cycles
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone." in: Nature communications, Vol. 7, pp. 13885, (2018) (PubMed).
: "Exercise-induced circulating extracellular vesicles protect against cardiac ischemia-reperfusion injury." in: Basic research in cardiology, Vol. 112, Issue 4, pp. 38, (2018) (PubMed).
: "Broadleaf Mahonia attenuates granulomatous lobular mastitis‑associated inflammation by inhibiting CCL‑5 expression in macrophages." in: International journal of molecular medicine, Vol. 41, Issue 1, pp. 340-352, (2018) (PubMed).
: "Serum Exosomes Attenuate H2O2-Induced Apoptosis in Rat H9C2 Cardiomyocytes via ERK1/2." in: Journal of cardiovascular translational research, (2018) (PubMed).
: "CDDO and ATRA Instigate Differentiation of IMR32 Human Neuroblastoma Cells." in: Frontiers in molecular neuroscience, Vol. 10, pp. 310, (2017) (PubMed).
: "The ω-carboxyl group of 7-ketocholesteryl-9-carboxynonanoate mediates the binding of oxLDL to CD36 receptor and enhances caveolin-1 expression in macrophages." in: The international journal of biochemistry & cell biology, Vol. 90, pp. 121-135, (2017) (PubMed).
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Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone." in: Nature communications, Vol. 7, pp. 13885, (2018) (PubMed).
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- 抗原
- ERK2 (MAPK1) (Mitogen-Activated Protein Kinase 1 (MAPK1))
- 别名
- MAPK1 (MAPK1 产品)
- 背景
- This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.,ERK,ERK-2,ERK2,ERT1,MAPK2,P42MAPK,PRKM1,PRKM2,p38,p40,p41,p41mapk,p42-MAPK,MAPK1,Epigenetics & Nuclear Signaling,Translation Control,Regulation of eIF4 and p70 S6 Kinase,Signal Transduction,G protein signaling,G2/M DNA Damage Checkpoint,Kinase,Serine/threonine kinases,mTOR Signaling Pathway,ErbB-HER Signaling Pathway,MAPK-Erk Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Mitochondrial Control of Apoptosis,Inhibition of Apoptosis,Cell Cycle,Centromere,Microtubules,TGF-b-Smad Signaling Pathway,ESC Pluripotency and Differentiation,Endocrine & Metabolism,Insulin Receptor Signaling Pathway,Warburg Effect,Immunology & Inflammation,B Cell Receptor Signaling Pathway,T Cell Receptor Signaling Pathway,IL-6 Receptor Signaling Pathway,Neuroscience,Neurodegenerative Diseases,Stem Cells,Cardiovascular,Angiogenesis,MAPK1
- 分子量
- 36 kDa/41 kDa
- 基因ID
- 5594
- UniProt
- P28482
- 途径
- MAPK Pathway, RTK signaling, Apoptosis, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Monocarboxylic Acid Catabolic Process, Autophagy, G-protein mediated Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals, BCR Signaling, S100 Proteins
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