This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.,HEL-215,HEL-S-54e,PHB1,PHB,Prohibitin,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Apoptosis,Cell Cycle,Cell cycle inhibitors,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial markers,PHB