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  • 抗原 See all Histone 3 (H3) 抗体
    Histone 3 (H3)
    抗原表位
    • 57
    • 49
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    • 42
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    • 40
    • 36
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    • 8
    H3K9me3
    适用
    • 1385
    • 957
    • 877
    • 59
    • 42
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    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    宿主
    • 1203
    • 239
    • 8
    • 5
    克隆类型
    • 1127
    • 327
    • 1
    多克隆
    标记
    • 796
    • 80
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    This Histone 3 antibody is un-conjugated
    应用范围
    • 1034
    • 407
    • 374
    • 314
    • 241
    • 188
    • 173
    • 166
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    • 153
    • 139
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    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Chromatin Immunoprecipitation (ChIP), Dot Blot (DB)
    交叉反应
    人, 小鼠, 大鼠
    产品特性
    Methylated Antibodies
    纯化方法
    Affinity purification
    免疫原
    A synthetic methylated peptide corresponding to residues surrounding K9 of human histone H3
    亚型
    IgG
    Top Product
    Discover our top product H3 Primary Antibody
  • 应用备注
    DB,1:500 - 1:2000,WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200,ChIP,1:50 - 1:200
    限制
    仅限研究用
  • 缓冲液
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • Zuo, Rong, Li, Lv, Lan, Tong: "The histone methyltransferase SETD2 is required for expression of acrosin-binding protein 1 and protamines and essential for spermiogenesis in mice." in: The Journal of biological chemistry, Vol. 293, Issue 24, pp. 9188-9197, (2019) (PubMed).

    Zhao, Zhang, Chen, Wang, Li, Cheng, Duan, Zhu, Wei, Li, Wu, Han, Yu, Gao, Li, Wong: "Dissecting the precise role of H3K9 methylation in crosstalk with DNA maintenance methylation in mammals." in: Nature communications, Vol. 7, pp. 12464, (2018) (PubMed).

    Fan, Lv, Huo, Wu, Wang, Cheng, Liu, Tang, Zhang, Zhang, Zheng, Wu, Wen: "The nuclear matrix protein HNRNPU maintains 3D genome architecture globally in mouse hepatocytes." in: Genome research, Vol. 28, Issue 2, pp. 192-202, (2018) (PubMed).

    Yu, Liu, Liu, Wang, Liu, Miao, Du, Yang: "Ascorbic acid induces global epigenetic reprogramming to promote meiotic maturation and developmental competence of porcine oocytes." in: Scientific reports, Vol. 8, Issue 1, pp. 6132, (2018) (PubMed).

    Cao, Liu, Yue, Liu, Pei, Gu, Wang, Jia: "Iron chelation inhibits cancer cell growth and modulates global histone methylation status in colorectal cancer." in: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, Vol. 31, Issue 5, pp. 797-805, (2018) (PubMed).

    Yin, Jiang, Jiang, Gao, Wang, Fan, Khan, Jabeen, Khan, Ali, Xu, Pandita, Fan, Zhang, Shi: "Histone acetyltransferase KAT8 is essential for mouse oocyte development by regulating reactive oxygen species levels." in: Development (Cambridge, England), Vol. 144, Issue 12, pp. 2165-2174, (2017) (PubMed).

    Zhao, Lei, Zhang, Zheng, Wang, Zhao, Li, Ye, Li, Wei, Wu: "Global histone modification profiling reveals the epigenomic dynamics during malignant transformation in a four-stage breast cancer model." in: Clinical epigenetics, Vol. 8, pp. 34, (2016) (PubMed).

  • 抗原
    Histone 3 (H3)
    别名
    Histone H3 (H3 产品)
    别名
    H-3 antibody, histocompatibility 3 antibody, H3 antibody
    背景
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails, instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3.,H3.4,H3/g,H3FT,H3t,HIST3H3,Histone H3,HIST1H3A,Signal Transduction,MAPK-Erk Signaling Pathway,MAPK-P38 Signaling Pathway,Epigenetics & Nuclear Signaling,Epigenetic Modifications,Methylation,Histone H3
    分子量
    15 kDa
    基因ID
    8290
    UniProt
    Q16695
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