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PLVAP 抗体

PLVAP 适用: 小鼠 FACS, IHC, IHC (fro) 宿主: 大鼠 Monoclonal MECA-32 unconjugated
产品编号 ABIN298904
发货至: 中国
  • 抗原 See all PLVAP 抗体
    PLVAP (Plasmalemma Vesicle Associated Protein (PLVAP))
    适用
    • 28
    • 6
    • 1
    小鼠
    宿主
    • 21
    • 7
    • 4
    大鼠
    克隆类型
    • 22
    • 9
    单克隆
    标记
    • 18
    • 5
    • 3
    • 2
    • 2
    • 2
    This PLVAP antibody is un-conjugated
    应用范围
    • 30
    • 21
    • 16
    • 8
    • 6
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro))
    特异性
    Recognizes murine plasmalemma vesicle-associated protein (PLVAP), a 60kD protein which is otherwise known as MECA-32 and PV-1. PLVAP is a transmembrane homodimer which is associated with endothelial cell caveolae and fenestrae. In adult and embryonic mice, PLVAP is primarily expressed on endothelial tissues but shows restricted distribution in the skeletal, cardiac and brain tissues. In embryonic mice, PLVAP expression, on the vasculature associated with blood brain barrier has been reported to be developmentally regulated. In humans, PLVAP is selectively up-regulated in a variety of high-grade brain tumors, including glioblastoma and metastatic carcinoma, as well as other cerebral disorders associated with blood-brain barrier disruption, such as acute ischemia. PLVAP represents a novel marker of brain tumor angiogenesis and integrity of the blood-brain barrier and is a potential therapeutic target.
    纯化方法
    Affinity purified
    免疫原


    Type of Immunogen: Native protein
    克隆位点
    MECA-32
    亚型
    IgG2a
    Top Product
    Discover our top product PLVAP Primary Antibody
  • 应用备注
    Approved: Flo, IHC, IHC-Fr (1:25 - 1:100)

    Usage: Flow Cytometry: Use 10 μL of the suggested working dilution to label 1x10^6 cells in 100 μL. Method sheets are available on request.
    说明

    Target Species of Antibody: Mouse

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    PBS, 0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    avoid freeze thaw cycles. Store undiluted.
    储存条件
    4 °C,-20 °C
    储存方法
    Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles. Store undiluted.
  • Simon-Santamaria, Rinaldo, Kardas, Li, Malovic, Elvevold, McCourt, Smedsrød, Hirsch, Sørensen: "Efficient uptake of blood-borne BK and JC polyomavirus-like particles in endothelial cells of liver sinusoids and renal vasa recta." in: PLoS ONE, Vol. 9, Issue 11, pp. e111762, (2015) (PubMed).

  • 抗原
    PLVAP (Plasmalemma Vesicle Associated Protein (PLVAP))
    别名
    PV1 / PLVAP (PLVAP 产品)
    别名
    MECA32 antibody, Pv1 antibody, FELS antibody, PV-1 antibody, PV1 antibody, gp68 antibody, plasmalemma vesicle associated protein antibody, Plvap antibody, PLVAP antibody
    背景
    Name/Gene ID: PLVAP

    Synonyms: PLVAP, gp68, FELS, Plasmalemma vesicle protein 1, PV-1, PV1
    基因ID
    83483
    UniProt
    Q9BX97
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