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RAGE 抗体

AGER 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN289974
发货至: 中国
  • 抗原 See all RAGE (AGER) 抗体
    RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))
    适用
    • 149
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    宿主
    • 136
    • 12
    • 4
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    克隆类型
    • 131
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    • 1
    多克隆
    标记
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    This RAGE antibody is un-conjugated
    应用范围
    • 117
    • 63
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    Western Blotting (WB)
    纯化方法
    This antibody was purified from rabbit serum by Protein G affinity chromatography.
    免疫原
    Partial peptide of Human RAGE
    Top Product
    Discover our top product AGER Primary Antibody
  • 限制
    仅限研究用
  • 浓度
    0.25 mg/ml
    缓冲液
    PBS (containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat)
    储存液
    ProClin
    储存条件
    -20 °C
  • 抗原
    RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))
    别名
    RAGE (AGER 产品)
    背景
    RAGE is the receptor of AGEs, advanced glycation end products with 35,000 molecularweight and was cloned from bovine lung in 1992 ( David Stern et al.,). RAGE has been foundin several tissues such as monocytes, macrophages, endothelial cells, astocytes. The ligand ofRAGE is demonstrated not only AGEs but also anfoterin, EN-RAGE,N-carboxymethyllysine(CML),beta-amyloid and so on. The accumulation of AGEs-proteins invivo has been demonstrated in several disease, it is not clear whether AGEs-proteinsaccumulated in vivo is a direct cause of the disease or rather reflects its effect. Regarding this issue, AGEs-modified proteins are known to interact with several cells by the AGEs-receptors and induce several cellular phenomena. Recently, it has been discovered that RAGE isinvolved in pathophysiological function of diabetes and Alzheimer
    途径
    Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, S100 Proteins
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