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Bcl-2 抗体 (N-Term)

Name: Bcl-2 抗体 (N-Term)
Brand: antibodies-online
SKU: ABIN2857047
Availability: OutOfStock

BCL2 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

WB Image Bcl-2 antibody detects Bcl-2 protein by Western blot analysis. (Bcl-2 抗体 (N-Term))

IHC-P Image Immunohistochemical analysis of paraffin-embedded human breast cancer, using Bcl-2, antibody at 1:250 dilution. (Bcl-2 抗体 (N-Term))

IHC

Expression of Bcl-2 family proteins in MCME-treated cancer cells. (Bcl-2 抗体 (N-Term))

Effects of quercetin on cell apoptosis in H2O2-treated H9C2 cells. (Bcl-2 抗体 (N-Term))

HH-F3 induces apoptosis in HCC cells. (Bcl-2 抗体 (N-Term))

High-dose NaF induced the occurrence of apoptosis in H9 hESCs. (Bcl-2 抗体 (N-Term))

Analysis of protein expression of the apoptosis biomarkers caspase 3 and Bax and the antiapoptosis indicator BCL-2 and a TUNEL assay in the urinary bladder at 4 days after IC induction (n=5). (Bcl-2 抗体 (N-Term))

HDAC2 and HDAC5 negatively regulate the expression of miR-125a-5p in ER+ breast cancer cells. (Bcl-2 抗体 (N-Term))

Overexpression of FKBP12. (Bcl-2 抗体 (N-Term))

Nox hyperactivity contributes to cardiomyocyte apoptosis in SAP rats. (Bcl-2 抗体 (N-Term))

The effect of 4-HPPP on Akt phosphorylation changes in NSCLC cells. (Bcl-2 抗体 (N-Term))

APD treatment enhances pancreatic acinar cell apoptosis in SAP rats. (Bcl-2 抗体 (N-Term))

IHC

The influence of intra-peritoneal injections PAAF with or without the PI3K inhibitor on PI3K/AKT signaling pathway. (Bcl-2 抗体 (N-Term))

IHC

Alb-Sch B co-therapy inhibits apoptosis in A. (Bcl-2 抗体 (N-Term))

16 images

(13 references)

产品编号 ABIN2857047

发货至: 中国

Datasheet as PDF

Key Features
- High quality Bcl-2 Primary Antibody for the detection of BCL2.
- Reliable product with high standard validation data
抗原 See all Bcl-2 (BCL2) 抗体

Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))
抗原表位
48

36

27

23

22

21

16

16

16

14

13

11

10

9

8

8

8

7

7

7

6

6

6

6

6

5

4

4

4

4

3

3

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1
N-Term
适用
427

163

162

34

23

22

17

9

6

5

5

2

1

1

1

1
人
宿主
348

108

5

2

1
兔
Compatible Secondaries
克隆类型
348

115
多克隆
标记
198

31

31

23

23

14

8

8

8

8

8

8

8

8

8

8

8

6

6

6

6

6

6

2

2

2

2

2

2

2

2

1

1

1

1
This Bcl-2 antibody is un-conjugated
应用范围
352

178

160

114

96

95

80

64

55

29

23

22

18

8

8

7

5

4

2

2

1

1

1

1

1

1
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

交叉反应

Cat, 犬, 人, 小鼠, 大鼠, 斑马鱼

产品特性

Rabbit Polyclonal antibody to BCL2 (B-cell CLL/lymphoma 2)
Bcl-2 antibody [N1N2], N-term

纯化方法

Purified by antigen-affinity chromatography.

免疫原

Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human Bcl-2. The exact sequence is proprietary.

亚型

IgG

Product Specific Information

What can the Bcl-2 Antibody ABIN2857047 be used for?

This polyclonal Bcl-2 Antibody detects Bcl-2. The Bcl-2 Antibody has been validated for various applications and can be used for the detection of Bcl-2 and derivatives by Western Blotting, Immunofluorescence, Immunohistochemistry (Paraffin-embedded Sections), Immunocytochemistry.

What validation data is available for this Bcl-2 Antibody?

The Primary Antibody is referenced in 13 publications and is characterized by a proven, very high reliability. It has currently 16 product images that show its performance in a variety of applications. The product is currently available in 100 μL quantity. Bcl-2 Antibody for the detection of Bcl-2 and derivatives.

What is the function of Bcl-2?

This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq, Jul 2008].
anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 81-131) antibody
BCL2 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated

anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 101-160) antibody
BCL2 适用: 人, 小鼠, 大鼠, 兔, Cow, 小鸡, Bacteria WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 2-211) antibody
BCL2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 1-100) antibody
BCL2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-B-Cell CLL/lymphoma 2 (BCL2) antibody
BCL2 适用: 人 WB, IHC, IP 宿主: 兔 Monoclonal unconjugated

anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 2-211) antibody
BCL2 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal D1 unconjugated

anti-B-Cell CLL/lymphoma 2 (BCL2) antibody
BCL2 适用: 人 WB, IHC, StM 宿主: 兔 Monoclonal BCL2-2210R unconjugated Recombinant Antibody

anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 41-54) antibody
BCL2 适用: 人 WB, IHC, FACS, IF, StM, ISt 宿主: 小鼠 Monoclonal 100-D5 unconjugated

anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 41-54) antibody
BCL2 适用: 人 WB, FACS, IP, IHC (p), ICC, IHC (fro) 宿主: 小鼠 Monoclonal Bcl-2-100 unconjugated

anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 41-54) antibody (PE)
BCL2 适用: 人 FACS 宿主: 小鼠 Monoclonal Bcl-2-100 PE

应用备注

WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

说明

Positive Control: BCL2-transfected 293T
Validation: Comparison, Orthogonal, Overexpression

限制

仅限研究用
状态

Liquid

浓度

0.2 mg/mL

缓冲液

1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Tvrdá, Ďuračka, Benko, Kováčik, Lovíšek, Gálová, Žiarovská, Schwarzová, Kačániová: "Ejaculatory Abstinence Affects the Sperm Quality in Normozoospermic Men-How Does the Seminal Bacteriome Respond?" in: International journal of molecular sciences, Vol. 24, Issue 4, (2023) (PubMed).

Lin, Lecca, Yang, Luo, Scerba, Tweedie, Huang, Jung, Kim, Yang, Hoffer, Wang, Greig: "3,6'-dithiopomalidomide reduces neural loss, inflammation, behavioral deficits in brain injury and microglial activation." in: eLife, Vol. 9, (2020) (PubMed).

Luo, Huang, Yuan, Yang, Wang, Huang, Tang, Sun: "Abdominal paracentesis drainage attenuates severe acute pancreatitis by enhancing cell apoptosis via PI3K/AKT signaling pathway." in: Apoptosis : an international journal on programmed cell death, Vol. 25, Issue 3-4, pp. 290-303, (2020) (PubMed).

Yang, Tang, Xu, Liu, Tan, Gao, Sun, Ding, Liu, Chen: "PI3K/mTORC1/2 inhibitor PQR309 inhibits proliferation and induces apoptosis in human glioblastoma cells." in: Oncology reports, Vol. 43, Issue 3, pp. 773-782, (2020) (PubMed).

Wen, Sun, Tan, Liu, Huang, Chen, Qi, Tang: "Abdominal paracentesis drainage ameliorates myocardial injury in severe experimental pancreatitis rats through suppressing oxidative stress." in: World journal of gastroenterology, Vol. 26, Issue 1, pp. 35-54, (2020) (PubMed).

Wu, Luo, Liu, Cui, Guo, Zhao, Guo, Bai, Guo, Feng, Qu et al.: "Recombinant adiponectin peptide promotes neuronal survival after intracerebral haemorrhage by suppressing mitochondrial and ATF4-CHOP apoptosis pathways in diabetic mice via Smad3 signalling ..." in: Cell proliferation, Vol. 53, Issue 2, pp. e12759, (2020) (PubMed).

Jiao, Li, Shao, Zhang, Gong, Yang, Wang, Tan, Sun, Xuan, Yu, Li, Gao, Liu, Xu, Li, Zhang, Zhang: "lncRNA-ZFAS1 induces mitochondria-mediated apoptosis by causing cytosolic Ca2+ overload in myocardial infarction mice model." in: Cell death & disease, Vol. 10, Issue 12, pp. 942, (2020) (PubMed).

Lam, Liang, Jiang, Peng: "Albendazole-Schisandrin B Co-Therapy on Angiostrongylus cantonensis-Induced Meningoencephalitis in Mice." in: Biomolecules, Vol. 10, Issue 7, (2020) (PubMed).

Wen, Liu, Lin, Luo, Tang, Huang, Sun, Tang: "NADPH Oxidase Hyperactivity Contributes to Cardiac Dysfunction and Apoptosis in Rats with Severe Experimental Pancreatitis through ROS-Mediated MAPK Signaling Pathway." in: Oxidative medicine and cellular longevity, Vol. 2019, pp. 4578175, (2019) (PubMed).

Batsaikhan, Wang, Scerba, Tweedie, Greig, Miller, Hoffer, Lin, Wang: "Post-Injury Neuroprotective Effects of the Thalidomide Analog 3,6'-Dithiothalidomide on Traumatic Brain Injury." in: International journal of molecular sciences, Vol. 20, Issue 3, (2019) (PubMed).

Xiao, Zeng, Guan, Wang, Wang, Shi, Shou, Deng, Xin: "FKBP12.6 protects heart from AngII-induced hypertrophy through inhibiting Ca2+ /calmodulin-mediated signalling pathways in vivo and in vitro." in: Journal of cellular and molecular medicine, Vol. 22, Issue 7, pp. 3638-3651, (2019) (PubMed).

Li, Luo, Dong, Liu, Wu, Zhang, Hu, Zhang, Song, Li: "Therapeutic effect of urine-derived stem cells for protamine/lipopolysaccharide-induced interstitial cystitis in a rat model." in: Stem cell research & therapy, Vol. 8, Issue 1, pp. 107, (2018) (PubMed).

Wang, Hsieh, Liu, Lin, Wu, Chen, Fang: "Reactive oxygen species-driven mitochondrial injury induces apoptosis by teroxirone in human non-small cell lung cancer cells." in: Oncology letters, Vol. 14, Issue 3, pp. 3503-3509, (2017) (PubMed).
抗原

Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

别名

BCL2 apoptosis regulator (BCL2 产品)

别名

Bcl-2 antibody, PPP1R50 antibody, bcl-2 antibody, AW986256 antibody, C430015F12Rik antibody, D630044D05Rik antibody, D830018M01Rik antibody, BCL-2 antibody, Bcl2 antibody, BCL2, apoptosis regulator antibody, B cell leukemia/lymphoma 2 antibody, B-cell CLL/lymphoma 2a antibody, B-cell CLL/lymphoma 2 protein antibody, BCL2 antibody, Bcl2 antibody, bcl2a antibody, BCL-2 antibody

背景

This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.

Cellular Localization: Mitochondrion outer membrane , Nucleus membrane , Endoplasmic reticulum membrane

分子量

26 kDa

基因ID

596

UniProt

P10415

途径

MAPK Pathway, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling