(1 reference)-
- 抗原 See all ITPK1 抗体
- ITPK1 (Inositol-Tetrakisphosphate 1-Kinase (ITPK1))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ITPK1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 交叉反应
- 人
- 产品特性
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Rabbit Polyclonal antibody to ITPK1 (inositol 1,3,4-triphosphate 5/6 kinase)
ITPK1 antibody [N3C3] - 纯化方法
- Purified by antigen-affinity chromatography.
- 免疫原
- Recombinant protein encompassing a sequence within the center region of human ITPK1. The exact sequence is proprietary.
- 亚型
- IgG
- Top Product
- Discover our top product ITPK1 Primary Antibody
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anti-Inositol-Tetrakisphosphate 1-Kinase (ITPK1) (AA 1-314) antibody
ITPK1 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-Inositol-Tetrakisphosphate 1-Kinase (ITPK1) (AA 1-314) antibodyITPK1 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 2C8 unconjugated
anti-Inositol-Tetrakisphosphate 1-Kinase (ITPK1) (AA 185-414) antibodyITPK1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Inositol-Tetrakisphosphate 1-Kinase (ITPK1) (AA 1-314) antibodyITPK1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Inositol-Tetrakisphosphate 1-Kinase (ITPK1) (AA 179-228) antibodyITPK1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Inositol-Tetrakisphosphate 1-Kinase (ITPK1) (AA 36-85) antibodyITPK1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, Pig, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Inositol-Tetrakisphosphate 1-Kinase (ITPK1) (AA 81-130) antibodyITPK1 适用: 人, 小鼠 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Inositol-Tetrakisphosphate 1-Kinase (ITPK1) (N-Term) antibodyITPK1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- 说明
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Positive Control: A431
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.53 mg/mL
- 缓冲液
- 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
- 储存液
- Thimerosal (Merthiolate)
- 注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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: "MLKL Requires the Inositol Phosphate Code to Execute Necroptosis." in: Molecular cell, Vol. 70, Issue 5, pp. 936-948.e7, (2019) (PubMed).
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: "MLKL Requires the Inositol Phosphate Code to Execute Necroptosis." in: Molecular cell, Vol. 70, Issue 5, pp. 936-948.e7, (2019) (PubMed).
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- 抗原
- ITPK1 (Inositol-Tetrakisphosphate 1-Kinase (ITPK1))
- 别名
- inositol-tetrakisphosphate 1-kinase (ITPK1 产品)
- 别名
- ITRPK1 antibody, BC031182 antibody, wu:fj15d08 antibody, zgc:56075 antibody, inositol-tetrakisphosphate 1-kinase antibody, inositol 1,3,4-triphosphate 5/6 kinase antibody, inositol-tetrakisphosphate 1-kinase L homeolog antibody, inositol-tetrakisphosphate 1-kinase a antibody, ITPK1 antibody, Itpk1 antibody, itpk1.L antibody, itpk1a antibody
- 背景
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Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetraphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain.
- 分子量
- 46 kDa
- 基因ID
- 3705
- UniProt
- Q13572
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