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GLUD1 抗体

GLUD1 适用: 人 WB, ELISA, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2856181
发货至: 中国
  • 抗原 See all GLUD1 抗体
    GLUD1 (Glutamate Dehydrogenase 1 (GLUD1))
    适用
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    宿主
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    克隆类型
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    多克隆
    标记
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    This GLUD1 antibody is un-conjugated
    应用范围
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    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    交叉反应
    Drosophila melanogaster, 人, 小鼠, 大鼠
    产品特性
    Rabbit Polyclonal antibody to Glutamate Dehydrogenase (glutamate dehydrogenase 1)
    Glutamate Dehydrogenase antibody
    纯化方法
    Purified by antigen-affinity chromatography.
    免疫原
    Recombinant protein encompassing a sequence within the center region of human Glutamate Dehydrogenase. The exact sequence is proprietary.
    亚型
    IgG
    Top Product
    Discover our top product GLUD1 Primary Antibody
  • 应用备注
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    说明

    Positive Control: 293T , A431 , HeLa , HepG2

    Validation: Orthogonal

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.07 mg/mL
    缓冲液
    1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Geiszler, Ugun-Klusek, Lawler, Pardon, Yuchun, Bai, Daykin, Auer, Bedford: "Dynamic metabolic patterns tracking neurodegeneration and gliosis following 26S proteasome dysfunction in mouse forebrain neurons." in: Scientific reports, Vol. 8, Issue 1, pp. 4833, (2019) (PubMed).

  • 抗原
    GLUD1 (Glutamate Dehydrogenase 1 (GLUD1))
    别名
    glutamate dehydrogenase 1 (GLUD1 产品)
    背景
    L-glutamate dehydrogenase (EC 1.4.1.3) has a central role in nitrogen metabolism in plants and animals. Glutamate dehydrogenase is found in all organisms and catalyzes the oxidative deamination of 1-glutamate to 2-oxoglutarate (Smith et al., 2001 [PubMed 11254391]). Glutamate, the main substrate of GLUD, is present in brain in concentrations higher than in other organs. In nervous tissue, GLUD appears to function in both the synthesis and the catabolism of glutamate and perhaps in ammonia detoxification (Mavrothalassitis et al., 1988 [PubMed 3368458]).[supplied by OMIM]

    Cellular Localization: Mitochondrion matrix
    分子量
    61 kDa
    基因ID
    2746
    UniProt
    P00367
    途径
    Positive Regulation of Peptide Hormone Secretion, Warburg Effect
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