Dystroglycan 抗体
(1 reference)-
- 抗原 See all Dystroglycan (DAG1) 抗体
- Dystroglycan (DAG1) (Dystroglycan 1 (DAG1))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Dystroglycan antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
- 交叉反应
- 马, 人, 小鼠, 大鼠
- 产品特性
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Rabbit Polyclonal antibody to alpha Dystroglycan (dystroglycan 1 (dystrophin-associated glycoprotein 1))
DAG1 antibody - 纯化方法
- Purified by antigen-affinity chromatography.
- 免疫原
- Recombinant protein encompassing a sequence within the center region of human DAG1. The exact sequence is proprietary.
- 亚型
- IgG
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anti-Dystroglycan 1 (DAG1) (AA 718-747), (C-Term) antibody
DAG1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB33752 unconjugated
anti-Dystroglycan 1 (DAG1) (AA 28-406) antibodyDAG1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Dystroglycan 1 (DAG1) (AA 31-140) antibodyDAG1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2A3 unconjugated
anti-Dystroglycan 1 (DAG1) (Internal Region) antibodyVerified DAG1 适用: 人 WB, ELISA, IHC, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Dystroglycan 1 (DAG1) (AA 726-744) antibodyDAG1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Dystroglycan 1 (DAG1) (C-Term) antibodyDAG1 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Dystroglycan 1 (DAG1) (AA 323-372) antibodyDAG1 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔, 马, 猴, Bat, 小鸡, Pig, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Dystroglycan 1 (DAG1) (AA 721-770) antibodyDAG1 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔, 猴, 豚鼠, Bat, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-Dystroglycan 1 (DAG1) (C-Term) antibodyDAG1 适用: 人 IHC, IHC (fro) 宿主: 小鼠 Monoclonal 43DAG1-8D5 unconjugated
anti-Dystroglycan 1 (DAG1) (AA 654-749) antibodyDAG1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- 说明
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Positive Control: U87-MG membrane fraction extract , MCF-7 membrane extracts , 293T membrane extracts
Validation: Orthogonal
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1.21 mg/mL
- 缓冲液
- 1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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: "Virus entry. Lassa virus entry requires a trigger-induced receptor switch." in: Science (New York, N.Y.), Vol. 344, Issue 6191, pp. 1506-10, (2014) (PubMed).
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: "Virus entry. Lassa virus entry requires a trigger-induced receptor switch." in: Science (New York, N.Y.), Vol. 344, Issue 6191, pp. 1506-10, (2014) (PubMed).
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- 抗原
- Dystroglycan (DAG1) (Dystroglycan 1 (DAG1))
- 别名
- dystroglycan 1 (DAG1 产品)
- 背景
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Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence.
Cellular Localization: Alpha-dystroglycan: Secreted , extracellular space , Beta-dystroglycan: Cell membrane , Cytoplasm , cytoskeleton - 分子量
- 97 kDa
- 基因ID
- 1605
- UniProt
- Q14118
- 途径
- Maintenance of Protein Location, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus
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