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- 抗原 See all CHFR 抗体
- CHFR (Checkpoint with Forkhead and Ring Finger Domains (CHFR))
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抗原表位
- C-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CHFR antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 交叉反应
- 人
- 产品特性
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Rabbit polyclonal antibody to CHFR (checkpoint with forkhead and ring finger domains)
CHFR antibody [C3], C-term - 纯化方法
- Purified by antigen-affinity chromatography.
- 免疫原
- Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human CHFR. The exact sequence is proprietary.
- 亚型
- IgG
- Top Product
- Discover our top product CHFR Primary Antibody
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anti-Checkpoint with Forkhead and Ring Finger Domains (CHFR) (AA 1-652) antibody
CHFR 适用: 人 ELISA, WB, IHC (p), RNAi 宿主: 小鼠 Monoclonal 1H3-A12 unconjugated
anti-Checkpoint with Forkhead and Ring Finger Domains (CHFR) (AA 141-422) antibodyCHFR 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Checkpoint with Forkhead and Ring Finger Domains (CHFR) (AA 136-194) antibodyCHFR 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 2B11 unconjugated
anti-Checkpoint with Forkhead and Ring Finger Domains (CHFR) antibodyCHFR 适用: 人, 小鼠, 大鼠 ELISA, WB, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Checkpoint with Forkhead and Ring Finger Domains (CHFR) (AA 36-85) antibodyCHFR 适用: 人, 小鼠, 大鼠, 兔, 斑马鱼, 豚鼠, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Checkpoint with Forkhead and Ring Finger Domains (CHFR) (C-Term) antibodyVerified CHFR 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Checkpoint with Forkhead and Ring Finger Domains (CHFR) (AA 1-290) antibodyCHFR 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Checkpoint with Forkhead and Ring Finger Domains (CHFR) (N-Term) antibodyCHFR 适用: 人, 小鼠, 大鼠, 兔, 斑马鱼, Cow, 犬, 马, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- 说明
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Positive Control: H1299 , NT2D1
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- 1XPBS ( pH 7), 40 % Glycerol, 0.01 % Thimerosal
- 储存液
- Thimerosal (Merthiolate)
- 注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- 抗原
- CHFR (Checkpoint with Forkhead and Ring Finger Domains (CHFR))
- 别名
- checkpoint with forkhead and ring finger domains (CHFR 产品)
- 别名
- RNF116 antibody, RNF196 antibody, CHFR antibody, fc43f10 antibody, si:dkey-69h6.7 antibody, wu:fc43f10 antibody, rnf116 antibody, rnf196 antibody, 5730484M20Rik antibody, C230082M18 antibody, checkpoint with forkhead and ring finger domains antibody, checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase antibody, checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase L homeolog antibody, CHFR antibody, chfr antibody, Chfr antibody, chfr.L antibody
- 背景
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E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress.
Cellular Localization: Nucleus - 分子量
- 73 kDa
- 基因ID
- 55743
- UniProt
- Q96EP1
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