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Lamin B1 抗体

KO Validated LMNB1 适用: 人 WB, IP, IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2855607
发货至: 中国
  • 抗原 See all Lamin B1 (LMNB1) 抗体
    Lamin B1 (LMNB1)
    适用
    • 64
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    宿主
    • 45
    • 21
    • 1
    克隆类型
    • 46
    • 21
    多克隆
    标记
    • 56
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
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    This Lamin B1 antibody is un-conjugated
    应用范围
    • 54
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    Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    交叉反应
    Hamster, 人, 小鼠
    产品特性
    Rabbit Polyclonal antibody to Lamin B1 (lamin B1)
    Lamin B1 antibody
    纯化方法
    Purified by antigen-affinity chromatography.
    质量等级
    KO Validated
    免疫原
    Recombinant protein encompassing a sequence within the center region of human Lamin B1. The exact sequence is proprietary.
    亚型
    IgG
    Top Product
    Discover our top product LMNB1 Primary Antibody
  • 应用备注
    WB: 1:500-1:20000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    说明

    Validatio: KO/KD, Orthogonal

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Siew, Chen, Chen, Chen, Chen, Soong, Wu, Chang, Chan, Lin, Liu, Chern: "Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington's disease." in: Nature communications, Vol. 10, Issue 1, pp. 3473, (2019) (PubMed).

    Silva, Pentz, Figueira, Arora, Lee, Hodson, Wischnewski, Deans, Azzalin: "FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops." in: Nature communications, Vol. 10, Issue 1, pp. 2253, (2019) (PubMed).

    Hsieh, Wang, Changou, Chin, Yang, Lai, Lee, Yang, Whang-Peng, Liu, Lin, Mousa, Davis: "Crosstalk between integrin αvβ3 and ERα contributes to thyroid hormone-induced proliferation of ovarian cancer cells." in: Oncotarget, Vol. 8, Issue 15, pp. 24237-24249, (2018) (PubMed).

    Arora, Lee, Wischnewski, Brun, Schwarz, Azzalin: "RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells." in: Nature communications, Vol. 5, pp. 5220, (2014) (PubMed).

  • 抗原
    Lamin B1 (LMNB1)
    别名
    lamin B1 (LMNB1 产品)
    别名
    MGC52550 antibody, Lamin-L(I) antibody, lamin-b antibody, lmn antibody, lmn2 antibody, lmnb antibody, LMNB1 antibody, ADLD antibody, LMN antibody, LMN2 antibody, LMNB antibody, fc06g01 antibody, wu:fc06g01 antibody, lamin B1 L homeolog antibody, lamin B1 antibody, lmnb1.L antibody, lmnb1 antibody, LMNB1 antibody, Lmnb1 antibody
    背景
    The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1.

    Cellular Localization: Nucleus inner membrane, Lipid-anchor, Nucleoplasmic side
    分子量
    66 kDa
    基因ID
    4001
    UniProt
    P20700
    途径
    Apoptosis, Caspase Cascade in Apoptosis
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