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Calpain 5 抗体

CAPN5 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2855597
发货至: 中国
  • 抗原 See all Calpain 5 (CAPN5) 抗体
    Calpain 5 (CAPN5)
    适用
    • 26
    • 15
    • 14
    宿主
    • 25
    • 4
    克隆类型
    • 26
    • 3
    多克隆
    标记
    • 21
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Calpain 5 antibody is un-conjugated
    应用范围
    • 17
    • 7
    • 6
    • 6
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
    交叉反应
    人, 小鼠
    产品特性
    Rabbit polyclonal antibody to Calpain-5 (calpain 5)
    Calpain-5 antibody [N1C1]
    纯化方法
    Purified by antigen-affinity chromatography.
    免疫原
    Recombinant protein encompassing a sequence within the center region of human Calpain 5. The exact sequence is proprietary.
    亚型
    IgG
  • 应用备注
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    说明

    Positive Control: mouse uterus , RMS-13

    Validation: Orthogonal, Overexpression

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1.39 mg/mL
    缓冲液
    1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Velez, Bassuk, Schaefer, Brooks, Gakhar, Mahajan, Kahn, Tsang, Ferguson, Mahajan: "A novel de novo CAPN5 mutation in a patient with inflammatory vitreoretinopathy, hearing loss, and developmental delay." in: Cold Spring Harbor molecular case studies, Vol. 4, Issue 3, (2019) (PubMed).

    Schaefer, Toral, Velez, Cox, Baker, Borcherding, Colgan, Bondada, Mashburn, Yu, Geddes, Tsang, Bassuk, Mahajan: "Calpain-5 Expression in the Retina Localizes to Photoreceptor Synapses." in: Investigative ophthalmology & visual science, Vol. 57, Issue 6, pp. 2509-21, (2016) (PubMed).

  • 抗原
    Calpain 5 (CAPN5)
    别名
    calpain 5 (CAPN5 产品)
    别名
    HTRA3 antibody, nCL-3 antibody, Htra3 antibody, capn5 antibody, MGC53448 antibody, MGC89353 antibody, CAPN5 antibody, zgc:153446 antibody, calpain 5 antibody, calpain 5 L homeolog antibody, calpain 5a antibody, calpain 6 antibody, CAPN5 antibody, Capn5 antibody, capn5.L antibody, capn5 antibody, capn5a antibody, Bm1_30735 antibody, Bm1_30740 antibody, CAPN6 antibody, LOAG_10085 antibody
    背景
    Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3.

    分子量
    73 kDa
    基因ID
    726
    UniProt
    O15484
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