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CDK4 抗体

Name: CDK4 抗体
Brand: antibodies-online
SKU: ABIN2855529
Availability: OutOfStock

KO Validated CDK4 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

WB Image Sample(30 μg of whole cell lysate) A:293T 12% SDS PAGE antibody diluted at 1:1000 (CDK4 抗体)

ICC/IF Image CDK4 antibody detects CDK4 protein at nucleus by immunofluorescent analysis. (CDK4 抗体)

IHC-P Image Immunohistochemical analysis of paraffin-embedded human gastric cancer, using CDK4, antibody at 1:500 dilution. (CDK4 抗体)

IHC

WB Image Sample (30 ug of whole cell lysate) A:NIH-3T3 12% SDS PAGE antibody diluted at 1:1000 (CDK4 抗体)

Citreoviridin caused cell cycle arrest in the Go/G1 phase. (CDK4 抗体)

PB downregulates several proteins related to cell cycle progression, morphology, cell-cell adhesion and cell migration. (CDK4 抗体)

Combination of bortezomib and citreoviridin inhibited cell cycle progression through different cell cycle regulators. (CDK4 抗体)

8 images

(2 references)

产品编号 ABIN2855529

发货至: 中国

Datasheet as PDF

抗原 See all CDK4 抗体

CDK4 (Cyclin-Dependent Kinase 4 (CDK4))
适用
107

66

51

19

8

6

4

3

2

1

1

1
人
宿主
93

34

2

1
兔
Compatible Secondaries
克隆类型
96

33
多克隆
标记
75

10

9

5

5

4

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This CDK4 antibody is un-conjugated
应用范围
107

48

32

24

16

15

15

13

12

10

4

4

2

2

1

1

1

1

1
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

交叉反应

Cow, 人, 小鼠, 大鼠

产品特性

Rabbit Polyclonal antibody to CDK4 (cyclin-dependent kinase 4)
CDK4 antibody

纯化方法

Purified by antigen-affinity chromatography.

质量等级

KO Validated

免疫原

Recombinant protein encompassing a sequence within the center region of human CDK4. The exact sequence is proprietary.

亚型

IgG
anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 211-303) antibody
CDK4 适用: 人 WB, ELISA, IF, RNAi 宿主: 小鼠 Monoclonal 4F11 unconjugated

anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 273-305), (C-Term) antibody
CDK4 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB03154 unconjugated

anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 6-295) antibody
CDK4 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 4 (CDK4) (N-Term) antibody
CDK4 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 201-303) antibody
CDK4 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 273-305) antibody
CDK4 适用: 人 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 241-303) antibody
CDK4 适用: 人, 小鼠, 大鼠, 绵羊 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 272-303), (C-Term) antibody
CDK4 适用: 大鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 272-303) antibody
CDK4 适用: 人, 大鼠 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 4 (CDK4) (C-Term) antibody
CDK4 适用: 人, 大鼠, 绵羊, Pig, 犬, Cow, 兔, 豚鼠, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

说明

Positive Control: PC-12 , 293T
Validation: KO/KD, Orthogonal

限制

仅限研究用
状态

Liquid

浓度

0.82 mg/mL

缓冲液

1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Chen, Huang, Lin, Fang: "Piperlongumine induces autophagy in biliary cancer cells via reactive oxygen species-activated Erk signaling pathway." in: International journal of molecular medicine, Vol. 44, Issue 5, pp. 1687-1696, (2020) (PubMed).

Li, Du, Aldana-Masangkay, Wang, Urak, Forman, Rosen, Chen: "Regulation of miR-34b/c-targeted gene expression program by SUMOylation." in: Nucleic acids research, Vol. 46, Issue 14, pp. 7108-7123, (2019) (PubMed).
抗原

CDK4 (Cyclin-Dependent Kinase 4 (CDK4))

别名

cyclin dependent kinase 4 (CDK4 产品)

别名

zgc:153726 antibody, CMM3 antibody, PSK-J3 antibody, Crk3 antibody, 8-6 antibody, CDK4 antibody, CDK4/6 antibody, CG5072 antibody, Cdk4/6 antibody, DmCdk4 antibody, Dmel\\CG5072 antibody, Pk53C antibody, Pk?7 antibody, cdk antibody, cdk4 antibody, cdk4/6 antibody, dCdk4 antibody, l(2)05428 antibody, l(2)0671 antibody, l(2)k06503 antibody, l(2)s4639 antibody, l(2)sh0671 antibody, xcdk4 antibody, cyclin-dependent kinase 4 antibody, cyclin dependent kinase 4 antibody, Cyclin-dependent kinase 4 antibody, cyclin-dependent kinase 4 L homeolog antibody, cdk4 antibody, CDK4 antibody, Cdk4 antibody, cdk4.L antibody

背景

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.

分子量

34 kDa

基因ID

1019

UniProt

P11802

途径

Cell Division Cycle, Mitotic G1-G1/S Phases, Regulation of Cell Size