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MAP3K8 抗体

MAP3K8 适用: 人 WB, IHC (p), IF, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2855464
发货至: 中国
  • 抗原 See all MAP3K8 抗体
    MAP3K8 (Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8))
    适用
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    宿主
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    克隆类型
    • 85
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    多克隆
    标记
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    This MAP3K8 antibody is un-conjugated
    应用范围
    • 54
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    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunocytochemistry (ICC)
    交叉反应
    人, 小鼠
    产品特性
    Rabbit Polyclonal antibody to MAP3K8 (mitogen-activated protein kinase kinase kinase 8)
    MAP3K8 antibody [N3C3]
    纯化方法
    Purified by antigen-affinity chromatography.
    免疫原
    Recombinant protein encompassing a sequence within the center region of human MAP3K8. The exact sequence is proprietary.
    亚型
    IgG
    Top Product
    Discover our top product MAP3K8 Primary Antibody
  • 应用备注
    WB: 1:5000-1:50000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    说明

    Positive Control: Lovo

    Validation: Orthogonal, Overexpression

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.33 mg/mL
    缓冲液
    1XPBS, 1 % BSA, 20 % Glycerol ( pH 7), 0.025 % ProClin 300
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • 抗原
    MAP3K8 (Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8))
    别名
    mitogen-activated protein kinase kinase kinase 8 (MAP3K8 产品)
    别名
    MAP3K8 antibody, COT antibody, EST antibody, ESTF antibody, MEKK8 antibody, TPL2 antibody, Tpl-2 antibody, c-COT antibody, Cot antibody, Cot/Tpl2 antibody, Est antibody, Estf antibody, Tpl2 antibody, D17TPL2 antibody, mitogen-activated protein kinase kinase kinase 8 antibody, MAP3K8 antibody, map3k8 antibody, Map3k8 antibody
    背景
    This gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 (NFKB1). This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity.

    分子量
    53 kDa
    基因ID
    1326
    UniProt
    P41279
    途径
    PI3K-Akt Signaling, TCR Signaling
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