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VEGFA 抗体 (C-Term)

VEGFA 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2855448
发货至: 中国
  • 抗原 See all VEGFA 抗体
    VEGFA (Vascular Endothelial Growth Factor A (VEGFA))
    抗原表位
    • 19
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    C-Term
    适用
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    宿主
    • 209
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    克隆类型
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    • 1
    多克隆
    标记
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    This VEGFA antibody is un-conjugated
    应用范围
    • 198
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    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    交叉反应
    人, 小鼠, 大鼠
    产品特性
    Rabbit Polyclonal antibody to VEGF (vascular endothelial growth factor A)
    VEGF antibody
    纯化方法
    Purified by antigen-affinity chromatography.
    免疫原
    Recombinant protein encompassing a sequence within the C-terminus region of human VEGF. The exact sequence is proprietary.
    亚型
    IgG
    Top Product
    Discover our top product VEGFA Primary Antibody
  • 应用备注
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    说明

    Validation: Orthogonal

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.17 mg/mL
    缓冲液
    1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Chen, Guo, Guo, Kong, Bai, Long: "Protective Effect of Vitamin C against Infancy Rat Corneal Injury Caused by Acute UVB Irradiation." in: BioMed research international, Vol. 2020, pp. 8089273, (2020) (PubMed).

    Long, Yan, He, Zhang, Wang, Li, Xue, Chen, An, Zhang: "Protective effects of hydrogen gas in a rat model of branch retinal vein occlusion via decreasing VEGF-α expression." in: BMC ophthalmology, Vol. 19, Issue 1, pp. 112, (2019) (PubMed).

    Chen, Wang, Wei, Tzeng, Lan, Cheng, Kuo: "Maintenance BEZ235 Treatment Prolongs the Therapeutic Effect of the Combination of BEZ235 and Radiotherapy for Colorectal Cancer." in: Cancers, Vol. 11, Issue 8, (2019) (PubMed).

    Toraih, Ibrahiem, Fawzy, Hussein, Al-Qahtani, Shaalan: "MicroRNA-34a: A Key Regulator in the Hallmarks of Renal Cell Carcinoma." in: Oxidative medicine and cellular longevity, Vol. 2017, pp. 3269379, (2018) (PubMed).

    Kumarasamy, Sun: "Demonstration of a potent RET transcriptional inhibitor for the treatment of medullary thyroid carcinoma based on an ellipticine derivative." in: International journal of oncology, Vol. 51, Issue 1, pp. 145-157, (2018) (PubMed).

    Jiang, Li, Li, Fang, Long: "Dickkopf‑related protein 1 induces angiogenesis by upregulating vascular endothelial growth factor in the synovial fibroblasts of patients with temporomandibular joint disorders." in: Molecular medicine reports, Vol. 12, Issue 4, pp. 4959-66, (2016) (PubMed).

  • 抗原
    VEGFA (Vascular Endothelial Growth Factor A (VEGFA))
    别名
    vascular endothelial growth factor A (VEGFA 产品)
    别名
    MVCD1 antibody, VEGF antibody, VPF antibody, Vegf antibody, Vegf120 antibody, Vegf164 antibody, Vegf188 antibody, Vpf antibody, vegf antibody, vegfa antibody, wu:fj82c06 antibody, VEGF-A antibody, VEGF164 antibody, eVEGF120 antibody, eVEGF164 antibody, vegf-a antibody, vpf antibody, vefg antibody, si:dkey-14d8.3 antibody, wu:fd42e02 antibody, vascular endothelial growth factor A antibody, vascular endothelial growth factor Aa antibody, vascular endothelial growth factor A L homeolog antibody, vascular endothelial growth factor Ab antibody, VEGFA antibody, Vegfa antibody, vegfaa antibody, vegfa.L antibody, vegfa antibody, vegfab antibody
    背景
    This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms.

    Cellular Localization: Secreted
    分子量
    27 kDa
    基因ID
    7422
    UniProt
    P15692
    途径
    RTK signaling, Glycosaminoglycan Metabolic Process, Regulation of Cell Size, Tube Formation, Signaling Events mediated by VEGFR1 and VEGFR2, Platelet-derived growth Factor Receptor Signaling, VEGFR1 Specific Signals, VEGF Signaling
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