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HYOU1 抗体 (C-Term)

HYOU1 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2855339
发货至: 中国
  • 抗原 See all HYOU1 抗体
    HYOU1 (Hypoxia Up Regulated 1 (HYOU1))
    抗原表位
    • 15
    • 3
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    • 2
    • 1
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    C-Term
    适用
    • 66
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    宿主
    • 45
    • 21
    克隆类型
    • 41
    • 26
    多克隆
    标记
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    This HYOU1 antibody is un-conjugated
    应用范围
    • 52
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    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
    交叉反应
    人, 小鼠, 植物, 大鼠
    产品特性
    Rabbit Polyclonal antibody to ORP150 (hypoxia up-regulated 1)
    ORP150 antibody [C2C3], C-term
    纯化方法
    Purified by antigen-affinity chromatography.
    免疫原
    Recombinant protein encompassing a sequence within the C-terminus region of human ORP150. The exact sequence is proprietary.
    亚型
    IgG
  • 应用备注
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    说明

    Positive Control: mouse liver , rat brain , MCF-7 , MDA-MB-231

    Validation: Orthogonal

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.41 mg/mL
    缓冲液
    0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
    储存液
    Thimerosal (Merthiolate)
    注意事项
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • 抗原
    HYOU1 (Hypoxia Up Regulated 1 (HYOU1))
    别名
    hypoxia up-regulated 1 (HYOU1 产品)
    别名
    GRP-170 antibody, Grp170 antibody, HSP12A antibody, ORP-150 antibody, ORP150 antibody, AI415631 antibody, CBP-140 antibody, Cab140 antibody, Orp150 antibody, id:ibd5056 antibody, wu:fd14c05 antibody, zgc:56019 antibody, HYOU1 antibody, orp150 antibody, GRP170 antibody, hypoxia up-regulated 1 antibody, hypoxia up-regulated protein 1 antibody, hypoxia up-regulated 1 S homeolog antibody, HYOU1 antibody, Hyou1 antibody, hyou1 antibody, LOC100380749 antibody, hyou1.S antibody
    背景
    The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal.

    Cellular Localization: Endoplasmic reticulum lumen
    分子量
    111 kDa
    基因ID
    10525
    UniProt
    Q9Y4L1
    途径
    ER-Nucleus Signaling, SARS-CoV-2 Protein Interactome
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