ADAMTSL2 抗体 (C-Term)
ADAMTSL2
适用: 人
WB, IHC (p)
宿主: 兔
Polyclonal
unconjugated
(2 references)-
- 抗原 See all ADAMTSL2 抗体
- ADAMTSL2 (ADAMTS-Like 2 (ADAMTSL2))
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抗原表位
- C-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ADAMTSL2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 交叉反应
- 人, 小鼠
- 产品特性
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Rabbit Polyclonal antibody to ADAMTSL2 (ADAMTS-like 2)
ADAMTSL2 antibody [C3], C-term - 纯化方法
- Purified by antigen-affinity chromatography.
- 免疫原
- Recombinant protein encompassing a sequence within the C-terminus region of human ADAMTSL2. The exact sequence is proprietary.
- 亚型
- IgG
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- 应用备注
- WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- 说明
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Positive Control: H1299
Validation: Orthogonal
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
- 储存液
- Thimerosal (Merthiolate)
- 注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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: "Geleophysic dysplasia: novel missense variants and insights into ADAMTSL2 intracellular trafficking." in: Molecular genetics and metabolism reports, Vol. 21, pp. 100504, (2019) (PubMed).
: "Interactions between lysyl oxidases and ADAMTS proteins suggest a novel crosstalk between two extracellular matrix families." in: Matrix biology : journal of the International Society for Matrix Biology, Vol. 75-76, pp. 114-125, (2019) (PubMed).
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: "Geleophysic dysplasia: novel missense variants and insights into ADAMTSL2 intracellular trafficking." in: Molecular genetics and metabolism reports, Vol. 21, pp. 100504, (2019) (PubMed).
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- 抗原
- ADAMTSL2 (ADAMTS-Like 2 (ADAMTSL2))
- 别名
- ADAMTS like 2 (ADAMTSL2 产品)
- 别名
- ADAMTSL2 antibody, GPHYSD1 antibody, A930008K15Rik antibody, tcp-1 antibody, RGD1305459 antibody, ADAMTS-like 2 antibody, ADAMTS like 2 antibody, ADAMTS-like protein 2 antibody, ADAMTSL2 antibody, adamtsl2 antibody, LOC100589493 antibody, Adamtsl2 antibody
- 背景
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This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) and ADAMTS-like protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene lacks the protease domain, and is therefore of a member of the the ADAMTS-like protein subfamily. It is a secreted glycoprotein that binds the cell surface and extracellular matrix, it also interacts with latent transforming growth factor beta binding protein 1. Mutations in this gene have been associated with geleophysic dysplasia.
Cellular Localization: Secreted - 分子量
- 105 kDa
- 基因ID
- 9719
- UniProt
- Q86TH1
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