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Fibrillarin 抗体

FBL 适用: 人 WB, IF, IP, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2855179
发货至: 中国
  • 抗原 See all Fibrillarin (FBL) 抗体
    Fibrillarin (FBL)
    适用
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    宿主
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    克隆类型
    • 41
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    多克隆
    标记
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    This Fibrillarin antibody is un-conjugated
    应用范围
    • 43
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    Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC)
    特异性
    IP/MS validation was supported by references (PMID:30377378)
    交叉反应
    人, 小鼠, 大鼠
    产品特性
    Rabbit Polyclonal antibody to Fibrillarin (fibrillarin)
    Fibrillarin antibody
    纯化方法
    Purified by antigen-affinity chromatography.
    免疫原
    Recombinant protein encompassing a sequence within the center region of human Fibrillarin. The exact sequence is proprietary.
    亚型
    IgG
    Top Product
    Discover our top product FBL Primary Antibody
  • 应用备注
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    说明

    Positive Control: Rat2 , 293T , H1299 , NIH-3T3

    Validation: IP/MS

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.01 % Thimerosal
    储存液
    Thimerosal (Merthiolate)
    注意事项
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • 抗原
    Fibrillarin (FBL)
    别名
    fibrillarin (FBL 产品)
    背景
    This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8 % of humans with the autoimmune disease scleroderma recognize fibrillarin.

    Cellular Localization: Nucleus , nucleolus
    分子量
    34 kDa
    基因ID
    2091
    UniProt
    P22087
    途径
    Ribonucleoside Biosynthetic Process
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