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GLA 抗体

KO Validated GLA 适用: 人 WB, IP, IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2854962
发货至: 中国
  • 抗原 See all GLA 抗体
    GLA (Galactosidase, alpha (GLA))
    适用
    • 69
    • 35
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    宿主
    • 79
    • 8
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    克隆类型
    • 82
    • 7
    多克隆
    标记
    • 35
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    • 1
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    This GLA antibody is un-conjugated
    应用范围
    • 64
    • 32
    • 17
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    • 13
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    Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    特异性
    Knockdown/Knockout validation was supported by customer review data.
    交叉反应
    人, 大鼠
    产品特性
    Rabbit Polyclonal antibody to Galactosidase alpha (galactosidase, alpha)
    Galactosidase alpha antibody [N1C2]
    纯化方法
    Purified by antigen-affinity chromatography.
    质量等级
    KO Validated
    免疫原
    Recombinant protein encompassing a sequence within the center region of human Galactosidase alpha. The exact sequence is proprietary.
    亚型
    IgG
    Top Product
    Discover our top product GLA Primary Antibody
  • 应用备注
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    说明

    Positive Control: HeLa , 293T , Rat lung

    Validation: KO/KD

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.157 mg/mL
    缓冲液
    1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Ivanova, Dao, Kasaci, Adewale, Fikry, Goker-Alpan: "Rapid Clathrin-Mediated Uptake of Recombinant α-Gal-A to Lysosome Activates Autophagy." in: Biomolecules, Vol. 10, Issue 6, (2020) (PubMed).

    Hingorani, Metcalf, Deming, Garman, Powers, Gierasch: "Ligand-promoted protein folding by biased kinetic partitioning." in: Nature chemical biology, Vol. 13, Issue 4, pp. 369-371, (2017) (PubMed).

  • 抗原
    GLA (Galactosidase, alpha (GLA))
    别名
    galactosidase alpha (GLA 产品)
    别名
    GALA antibody, Ags antibody, zgc:101584 antibody, MGC130872 antibody, SMU.877 antibody, SCF11.21 antibody, AO090005000217 antibody, alpha-GAL antibody, galactosidase alpha antibody, galactosidase, alpha antibody, galactosidase alpha S homeolog antibody, alpha-galactosidase antibody, aga antibody, alpha-galactosidase A antibody, GLA antibody, Gla antibody, gla antibody, gla.S antibody, agaN antibody, aga antibody, agaL antibody, SCO0541 antibody, rafA antibody, melA antibody, galA antibody, ANI_1_2528074 antibody, ANI_1_1502124 antibody, AOR_1_390174 antibody, CpipJ_CPIJ002066 antibody, MCYG_00962 antibody, MCYG_00791 antibody, Tsp_02909 antibody, Tsp_02508 antibody
    背景
    This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties.

    Cellular Localization: Lysosome
    分子量
    49 kDa
    基因ID
    2717
    UniProt
    P06280
    途径
    SARS-CoV-2 Protein Interactome
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