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PPARA 抗体 (N-Term)

KO Validated PPARA 适用: 人 WB, IP, IHC (p), ChIP 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2854934
发货至: 中国
  • 抗原 See all PPARA 抗体
    PPARA (Peroxisome Proliferator-Activated Receptor alpha (PPARA))
    抗原表位
    • 16
    • 16
    • 15
    • 8
    • 7
    • 7
    • 6
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    • 1
    • 1
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    N-Term
    适用
    • 104
    • 94
    • 69
    • 18
    • 7
    • 6
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    • 5
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    • 4
    • 3
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    宿主
    • 103
    • 18
    克隆类型
    • 105
    • 16
    多克隆
    标记
    • 56
    • 8
    • 6
    • 6
    • 4
    • 3
    • 3
    • 3
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    • 3
    • 3
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    • 3
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    • 2
    • 1
    • 1
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    This PPARA antibody is un-conjugated
    应用范围
    • 105
    • 47
    • 41
    • 39
    • 39
    • 16
    • 14
    • 13
    • 9
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    Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Chromatin Immunoprecipitation (ChIP)
    交叉反应
    Bee, 人, 小鼠, 植物, 大鼠
    产品特性
    Rabbit Polyclonal antibody to PPAR alpha (peroxisome proliferator-activated receptor alpha)
    PPAR alpha antibody
    纯化方法
    Purified by antigen-affinity chromatography.
    质量等级
    KO Validated
    免疫原
    Recombinant protein encompassing a sequence within the N-terminus region of human PPAR alpha. The exact sequence is proprietary.
    亚型
    IgG
    Top Product
    Discover our top product PPARA Primary Antibody
  • 应用备注
    WB: 1:500-1:3000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    说明

    Validation: KO/KD, Orthogonal, Overexpression

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.39 mg/mL
    缓冲液
    1XPBS pH 7, 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Kubo, Hoshi, Matsumoto, Irie, Oura, Tsutsumi, Hata, Yamamoto, Saito: "Sake lees extract improves hepatic lipid accumulation in high fat diet-fed mice." in: Lipids in health and disease, Vol. 16, Issue 1, pp. 106, (2018) (PubMed).

    Song, Qu, Zhang, Jiang, Zhou, Jiang, Li, Zhang, Yan: "Phytosterol esters attenuate hepatic steatosis in rats with non-alcoholic fatty liver disease rats fed a high-fat diet." in: Scientific reports, Vol. 7, pp. 41604, (2018) (PubMed).

    Chung, Liu, Lin, Chi, Huang, Yang, Yeh, Tan, Lin: "ChIP-on-chip analysis of thyroid hormone-regulated genes and their physiological significance." in: Oncotarget, Vol. 7, Issue 16, pp. 22448-59, (2017) (PubMed).

  • 抗原
    PPARA (Peroxisome Proliferator-Activated Receptor alpha (PPARA))
    别名
    peroxisome proliferator activated receptor alpha (PPARA 产品)
    别名
    NR1C1 antibody, PPAR antibody, PPARalpha antibody, hPPAR antibody, LOC100136415 antibody, PPARALPHA antibody, nr1c1 antibody, xPPARalpha antibody, xppara antibody, 4933429D07Rik antibody, AW742785 antibody, Nr1c1 antibody, PPAR-alpha antibody, Ppar antibody, peroxisome proliferator activated receptor alpha antibody, peroxisome proliferator-activated receptor alpha antibody, peroxisome proliferator activated receptor alpha L homeolog antibody, PPARA antibody, LOC100136415 antibody, ppara.L antibody, Ppara antibody, ppara antibody
    背景
    Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers, this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined.

    分子量
    52 kDa
    基因ID
    5465
    UniProt
    Q07869
    途径
    Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha, Regulation of Carbohydrate Metabolic Process, Hepatitis C
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