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ube3a 抗体

ube3a 适用: 人 IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2854930
发货至: 中国
  • 抗原 See all ube3a 抗体
    ube3a (Ubiquitin Protein Ligase E3A (ube3a))
    适用
    • 51
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    • 4
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    宿主
    • 47
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    克隆类型
    • 46
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    多克隆
    标记
    • 28
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    • 1
    • 1
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    This ube3a antibody is un-conjugated
    应用范围
    • 28
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    • 16
    • 13
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    • 8
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    • 8
    • 4
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    Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
    交叉反应
    人, 小鼠, 大鼠
    产品特性
    Rabbit Polyclonal antibody to UBE3A (ubiquitin protein ligase E3A)
    UBE3A antibody
    纯化方法
    Purified by antigen-affinity chromatography.
    免疫原
    Recombinant protein encompassing a sequence within the center region of human UBE3A. The exact sequence is proprietary.
    亚型
    IgG
    Top Product
    Discover our top product ube3a Primary Antibody
  • 应用备注
    ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1.26 mg/mL
    缓冲液
    1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • 抗原
    ube3a (Ubiquitin Protein Ligase E3A (ube3a))
    别名
    ubiquitin protein ligase E3A (ube3a 产品)
    背景
    This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.

    Cellular Localization: Nucleus
    分子量
    100 kDa
    基因ID
    7337
    UniProt
    Q05086
    途径
    Intracellular Steroid Hormone Receptor Signaling Pathway
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