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- 抗原 See all KNG1 抗体
- KNG1 (Kininogen 1 (KNG1))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This KNG1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
- 交叉反应
- 人
- 产品特性
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Rabbit Polyclonal antibody to HMW Kininogen (kininogen 1)
HMW Kininogen antibody - 纯化方法
- Purified by antigen-affinity chromatography.
- 免疫原
- Recombinant protein encompassing a sequence within the center region of human HMW Kininogen. The exact sequence is proprietary.
- 亚型
- IgG
- Top Product
- Discover our top product KNG1 Primary Antibody
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anti-Kininogen 1 (KNG1) (AA 390-644) antibody
KNG1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Kininogen 1 (KNG1) (N-Term) antibodyKNG1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Kininogen 1 (KNG1) (AA 19-380) antibodyKNG1 适用: 大鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Kininogen 1 (KNG1) (AA 378-430) antibodyKNG1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C9 unconjugated
anti-Kininogen 1 (KNG1) (AA 148-427) antibodyKNG1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Kininogen 1 (KNG1) (AA 22-379) antibodyKNG1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Kininogen 1 (KNG1) (AA 390-644) antibodyKNG1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Kininogen 1 (KNG1) (AA 1-427) antibodyKNG1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Kininogen 1 (KNG1) (AA 1-427) antibodyKNG1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Kininogen 1 (KNG1) (AA 322-427) antibodyKNG1 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 4A1 unconjugated
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- 应用备注
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- 说明
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Positive Control: Molt-4
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
- 储存液
- Thimerosal (Merthiolate)
- 注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- 抗原
- KNG1 (Kininogen 1 (KNG1))
- 别名
- kininogen 1 (KNG1 产品)
- 别名
- BDK antibody, BK antibody, KNG antibody, Kng antibody, KNG2 antibody, fb64g01 antibody, wu:fb64g01 antibody, zgc:103569 antibody, kininogen antibody, bdk antibody, kng antibody, KNG1 antibody, IHRP antibody, KINKG antibody, KINKH antibody, Kng1 antibody, Kngk antibody, kininogen 1 antibody, kininogen 1 L homeolog antibody, inter-alpha-trypsin inhibitor heavy chain family member 4 antibody, kininogen 2-like 1 antibody, KNG1 antibody, Kng1 antibody, kng1 antibody, kng1.L antibody, ITIH4 antibody, Kng2l1 antibody
- 背景
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High molecular weight kininogen (HMWK) plays an important role in assembly of the plasma kallikrein (see MIM 147910)-kinin system. The KNG1 gene generates both HMWK and low molecular weight kininogen (LMWK) through alternative splicing. Both HMWK and LMWK contain an identical heavy chain consisting of protein domains 1, 2, and 3. However, HMWK contains a 56-kD light chain that consists of domains 5 and 6H, whereas LMWK contains a unique 4-kD light chain that consists of domain 5L. In both proteins, the heavy and light chains are linked by domain 4, which contains the bradykinin (BK) nonapeptide. BK, which is released by plasma kallikrein, is a potent inflammatory mediator that causes vasodilation and enhanced capillary permeability, induces pain, and stimulates production of nitric oxide and prostacyclin (see MIM 601699) from endothelial cells. During vascular damage, BK stimulates smooth muscle proliferation and intimal hypertrophy. Release of BK from HMWK generates a 2-chain HMWK, termed HMWKa, containing the heavy and light chains joined by a disulfide bond (Merkulov et al., 2008 [PubMed 18000168]).[supplied by OMIM]
- 分子量
- 72 kDa
- 基因ID
- 3827
- UniProt
- P01042
- 途径
- ACE Inhibitor Pathway, Glycosaminoglycan Metabolic Process
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