ACSL4 抗体 (C-Term)
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- 抗原 See all ACSL4 抗体
- ACSL4 (Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4))
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抗原表位
- C-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ACSL4 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunoprecipitation (IP)
- 交叉反应
- 人, 小鼠, 大鼠
- 产品特性
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Rabbit Polyclonal antibody to FACL4 (acyl-CoA synthetase long-chain family member 4)
FACL4 antibody [C3], C-term - 纯化方法
- Purified by antigen-affinity chromatography.
- 免疫原
- Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human FACL4. The exact sequence is proprietary.
- 亚型
- IgG
- Top Product
- Discover our top product ACSL4 Primary Antibody
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- 应用备注
- WB: 1:500-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:1000-1:5000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.44 mg/mL
- 缓冲液
- 1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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Immunohistochemical staining reveals differential expression of ACSL3 and ACSL4 in hepatocellular carcinoma and hepatic gastrointestinal metastases." in: Bioscience reports, Vol. 40, Issue 4, (2020) (PubMed).
: "Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death." in: Nature, Vol. 567, Issue 7746, pp. 118-122, (2019) (PubMed).
: "The endogenous subcellular localisations of the long chain fatty acid-activating enzymes ACSL3 and ACSL4 in sarcoma and breast cancer cells." in: Molecular and cellular biochemistry, Vol. 448, Issue 1-2, pp. 275-286, (2018) (PubMed).
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Immunohistochemical staining reveals differential expression of ACSL3 and ACSL4 in hepatocellular carcinoma and hepatic gastrointestinal metastases." in: Bioscience reports, Vol. 40, Issue 4, (2020) (PubMed).
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- 抗原
- ACSL4 (Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4))
- 别名
- acyl-CoA synthetase long chain family member 4 (ACSL4 产品)
- 别名
- acsl4 antibody, zgc:66186 antibody, ACSL4 antibody, ACS4 antibody, FACL4 antibody, LACS4 antibody, MRX63 antibody, MRX68 antibody, 9430020A05Rik antibody, AU018108 antibody, Facl4 antibody, Lacs4 antibody, Acs4 antibody, acs4 antibody, acsl3 antibody, facl4 antibody, lacs4 antibody, mrx63 antibody, mrx68 antibody, T32A16.20 antibody, T32A16_20 antibody, long-chain acyl-CoA synthetase 4 antibody, acyl-CoA synthetase long chain family member 4a antibody, acyl-CoA synthetase long-chain family member 4 antibody, acyl-CoA synthetase long chain family member 4 antibody, AcsL4 antibody, acyl-CoA synthetase long chain family member 3 antibody, Long-chain-fatty-acid--CoA ligase 4 antibody, acyl-CoA synthetase long-chain family member 4 S homeolog antibody, AMP-dependent synthetase and ligase family protein antibody, acsl4a antibody, ACSL4 antibody, acsL4 antibody, acsl3 antibody, acsl4 antibody, Acsl4 antibody, acsl4.S antibody, LACS4 antibody
- 背景
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The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants.
Cellular Localization: Mitochondrion outer membrane, Single-pass type III membrane protein , Peroxisome membrane, Single-pass type III membrane protein , Microsome membrane, Single-pass type III membrane protein , Endoplasmic reticulum membrane, Single-pass type III membrane pr - 分子量
- 79 kDa
- 基因ID
- 2182
- UniProt
- O60488
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