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IL12RB1 抗体

IL12RB1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2854451
发货至: 中国
  • 抗原 See all IL12RB1 抗体
    IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))
    适用
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    宿主
    • 54
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    克隆类型
    • 57
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    多克隆
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    This IL12RB1 antibody is un-conjugated
    应用范围
    • 42
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    Western Blotting (WB)
    交叉反应
    产品特性
    Rabbit polyclonal antibody to IL-12R beta1(CD212) (interleukin 12 receptor, beta 1)
    IL12 Receptor beta1 antibody [N1C2]
    纯化方法
    Purified by antigen-affinity chromatography.
    免疫原
    Recombinant protein encompassing a sequence within the center region of human IL12 Receptor beta1. The exact sequence is proprietary.
    亚型
    IgG
    Top Product
    Discover our top product IL12RB1 Primary Antibody
  • 应用备注
    WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    说明

    Positive Control: A431

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
    储存液
    Thimerosal (Merthiolate)
    注意事项
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • 抗原
    IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))
    别名
    interleukin 12 receptor subunit beta 1 (IL12RB1 产品)
    别名
    Il12rb antibody, IL12RB1 antibody, IL-12R antibody, CD212 antibody, IL-12R-BETA1 antibody, IL12RB antibody, IL-12R[b] antibody, interleukin 12 receptor subunit beta 1 antibody, interleukin 12 receptor, beta 1 antibody, Il12rb1 antibody, IL12RB1 antibody
    背景
    The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

    Cellular Localization: Membrane, Single-pass type I membrane protein
    分子量
    73 kDa
    基因ID
    3594
    UniProt
    P42701
    途径
    JAK/STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
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