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Dynactin 1 抗体 (AA 251-350) (AbBy Fluor® 594)

DCTN1 适用: 人 WB, IF (cc), IF (p) 宿主: 兔 Polyclonal AbBy Fluor® 594
产品编号 ABIN2812280
发货至: 中国
  • 抗原 See all Dynactin 1 (DCTN1) 抗体
    Dynactin 1 (DCTN1)
    抗原表位
    • 14
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 251-350
    适用
    • 53
    • 20
    • 14
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    宿主
    • 38
    • 12
    • 3
    • 1
    克隆类型
    • 42
    • 12
    多克隆
    标记
    • 34
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Dynactin 1 antibody is conjugated to AbBy Fluor® 594
    应用范围
    • 45
    • 17
    • 13
    • 12
    • 12
    • 7
    • 6
    • 6
    • 5
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    预测反应
    Human,Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human DCTN1/Dynactin 1
    亚型
    IgG
    Top Product
    Discover our top product DCTN1 Primary Antibody
  • 应用备注
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    有效期
    12 months
  • 抗原
    Dynactin 1 (DCTN1)
    别名
    DCTN1 (DCTN1 产品)
    别名
    DAP-150 antibody, DP-150 antibody, P135 antibody, Chip150 antibody, DCTN1 antibody, DKFZp469C1813 antibody, AL022633 antibody, Glued antibody, p150 antibody, p150 antibody, CG9206 antibody, DYNA_DROME antibody, Dmel\\CG9206 antibody, FCP-D antibody, Glu antibody, P150 antibody, P150[Glued] antibody, p150/Glued antibody, p150/glued antibody, p150[Glued] antibody, p150[glued] antibody, t1 antibody, Dynactin-1 antibody, glued antibody, dynactin subunit 1 antibody, dynactin 1 antibody, Dynactin 1, p150 subunit antibody, dynactin subunit 1 L homeolog antibody, DCTN1 antibody, Dctn1 antibody, DCTN1-p150 antibody, dctn1.L antibody
    背景

    Synonyms: Alternative names150 kDa dynein associated polypeptide, 150 kDa dynein-associated polypeptide, DAP 150, DAP-150, DAP150, DCTN 1, DCTN1, DCTN1_HUMAN, DP 150, DP-150, DP150, Dynactin 1 p150 Glued Drosophila homolog, Dynactin 1 p150 glued homolog Drosophila, Dynactin 1, Dynactin subunit 1, Dynactin1, HMN7B, P135, p150 Glued Drosophila homolog, p150 glued, p150 glued homolog, p150GLUED DROSOPHILA HOMOLOG OF, p150-glued, p150glued.

    Background: Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.Tissue specificity, Brain.Involvement in disease, Defects in DCTN1 are the cause of distal hereditary motor neuronopathy type 7B (HMN7B), also known as progressive lower motor neuron disease (PLMND). HMN7B is a neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs.Defects in DCTN1 are a cause of susceptibility to amyotrophic lateral sclerosis (ALS). ALS is a neurodegenerative disorder affecting upper and lower motor neurons, and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology is likely to be multifactorial, involving both genetic and environmental factors.Defects in DCTN1 are the cause of Perry syndrome (PERRYS), also called parkinsonism with alveolar hypoventilation and mental depression. Perry syndrome is a neuropsychiatric disorder characterized by mental depression not responsive to antidepressant drugs or electroconvulsive therapy, sleep disturbances, exhaustion and marked weight loss. Parkinsonism develops later and respiratory failure occurred terminally.

    基因ID
    1639
    途径
    M Phase, ER-Nucleus Signaling
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