ARFGEF1 抗体 (AA 1-200) (AbBy Fluor® 594)
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- 抗原 See all ARFGEF1 抗体
- ARFGEF1 (ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 1(brefeldin A-Inhibited) (ARFGEF1))
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抗原表位
- AA 1-200
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适用
- 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ARFGEF1 antibody is conjugated to AbBy Fluor® 594
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应用范围
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- 交叉反应
- 小鼠
- 预测反应
- Human,Rat,Dog,Cow,Sheep,Pig,Chicken
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human BIG1/ARFGEF1
- 亚型
- IgG
- Top Product
- Discover our top product ARFGEF1 Primary Antibody
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anti-ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 1(brefeldin A-Inhibited) (ARFGEF1) (AA 311-411) antibody
ARFGEF1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3E11 unconjugated
anti-ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 1(brefeldin A-Inhibited) (ARFGEF1) (AA 220-420) antibodyARFGEF1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- ARFGEF1 (ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 1(brefeldin A-Inhibited) (ARFGEF1))
- 别名
- BIG1/ARFGEF1 (ARFGEF1 产品)
- 别名
- ARFGEF1 antibody, ARFGEP1 antibody, BIG1 antibody, P200 antibody, D130059B05Rik antibody, D730028O18Rik antibody, RGD1560793 antibody, ADP ribosylation factor guanine nucleotide exchange factor 1 antibody, brefeldin A-inhibited guanine nucleotide-exchange protein 1 antibody, ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) antibody, ARFGEF1 antibody, CpipJ_CPIJ004831 antibody, Arfgef1 antibody
- 背景
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Synonyms: ADPribosylation factor guanine nucleotide exchange factor 1brefeldin A inhibited, ARFGEF1, ARFGEP1, Brefeldin A inhibited GEP 1, Brefeldin A inhibited guanine nucleotide exchange protein 1, p200 ARF GEP1, p200 ARF guanine nucleotide exchange factor, BIG1_HUMAN.
Background: Guanine nucleotide-exchange proteins (GEPs) accelerate replacement of bound GDP with GTP and thereby activate ADP-ribosylation factors (ARFs), a family of guanine nucleotide-binding proteins that play an important role in intracellular vesicular trafficking. GEPs comprise two major families, large GEPs that are inhibited by brefeldin A (BFA), a protein that effects Golgi structure and a group of smaller GEPs that are insenstive to BFA. Two genes for GEPs found on human chromosomes 8 and 20 encode BFA sensitive GEPs designated BIG1 and BIG2. Both GEPS contain a sec7 domain that is responsible for their brefeldin inhibition and also their catalytic activity. In vivo, BIG1 and BIG2 exist in macromolecular complexes that move between the Golgi membranes and cytosol. BIG2 associates with PKA regulatory subunits, implying that BIG2 may act as an A kinase-anchoring protein (AKAP) that could coordinate the cAMP and ARF regulatory pathways.
- 基因ID
- 10565
- 途径
- Regulation of Actin Filament Polymerization, Regulation of Carbohydrate Metabolic Process
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