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Dematin 抗体 (AA 201-300) (Biotin)

EPB49 适用: 人 WB, ELISA, IHC (p), IHC (fro) 宿主: 兔 Polyclonal Biotin
产品编号 ABIN2808184
发货至: 中国
  • 抗原 See all Dematin (EPB49) 抗体
    Dematin (EPB49) (erythrocyte Membrane Protein Band 4.9 (Dematin) (EPB49))
    抗原表位
    • 14
    • 7
    • 7
    • 6
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    AA 201-300
    适用
    • 54
    • 15
    • 5
    • 5
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    宿主
    • 52
    • 2
    克隆类型
    • 54
    多克隆
    标记
    • 25
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Dematin antibody is conjugated to Biotin
    应用范围
    • 48
    • 27
    • 13
    • 13
    • 11
    • 7
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    交叉反应
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human Dematin
    亚型
    IgG
    Top Product
    Discover our top product EPB49 Primary Antibody
  • 应用备注
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C for 12 months.
    有效期
    12 months
  • 抗原
    Dematin (EPB49) (erythrocyte Membrane Protein Band 4.9 (Dematin) (EPB49))
    别名
    Dematin (EPB49 产品)
    别名
    MGC80597 antibody, MGC108072 antibody, EPB49 antibody, DMT antibody, AI325486 antibody, Epb4.9 antibody, Epb49 antibody, dematin antibody, dematin actin binding protein L homeolog antibody, dematin actin binding protein antibody, dmtn.L antibody, DMTN antibody, dmtn antibody, Dmtn antibody
    背景

    Synonyms: DMT, EPB49, Dematin, Dematin actin-binding protein, Erythrocyte membrane protein band 4.9, DMTN

    Background: Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts, acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation.

    基因ID
    2039
    UniProt
    Q08495
    途径
    Regulation of Actin Filament Polymerization
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