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GCM1 抗体 (N-Term)

GCM1 适用: 人, 小鼠, 大鼠, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2792608
发货至: 中国
  • 抗原 See all GCM1 抗体
    GCM1 (Glial Cells Missing Homolog 1 (GCM1))
    抗原表位
    • 16
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    N-Term
    适用
    • 26
    • 20
    • 19
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠, 犬
    宿主
    • 24
    • 3
    克隆类型
    • 24
    • 3
    多克隆
    标记
    • 12
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GCM1 antibody is un-conjugated
    应用范围
    • 27
    • 14
    • 13
    • 13
    • 7
    • 5
    • 3
    • 3
    • 2
    Western Blotting (WB), Immunohistochemistry (IHC)
    序列
    MEPDDFDSED KEILSWDIND VKLPQNVKKT DWFQEWPDSY AKHIYSSEDK
    交叉反应
    犬, 人, 小鼠, 大鼠
    预测反应
    Dog: 78%, Human: 92%, Mouse: 78%, Rat: 78%
    产品特性
    This is a rabbit polyclonal antibody against GCM1. It was validated on Western Blot and immunohistochemistry.
    纯化方法
    Affinity Purified
    免疫原
    The immunogen is a synthetic peptide directed towards the N terminal region of human GCM1
  • 应用备注
    WB Suggested Anti-GCM1 Antibody Titration: 0.2-1 µg/mL
    ELISA Titer: 1:7812500
    Positive Control: Human Placenta.
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 436 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Bailey, Alahari, Tagliaferro, Post, Caniggia: "Augmented trophoblast cell death in preeclampsia can proceed via ceramide-mediated necroptosis." in: Cell death & disease, Vol. 8, Issue 2, pp. e2590, (2017) (PubMed).

    Moretto Zita, Soncin, Natale, Pizzo, Parast: "Gene Expression Profiling Reveals a Novel Regulatory Role for Sox21 Protein in Mouse Trophoblast Stem Cell Differentiation." in: The Journal of biological chemistry, Vol. 290, Issue 50, pp. 30152-62, (2015) (PubMed).

    Sivasubramaniyam, Garcia, Tagliaferro, Melland-Smith, Chauvin, Post, Todros, Caniggia: "Where polarity meets fusion: role of Par6 in trophoblast differentiation during placental development and preeclampsia." in: Endocrinology, Vol. 154, Issue 3, pp. 1296-309, (2013) (PubMed).

    Kumar, Luo, Tudela, Alexander, Mendelson: "The c-Myc-regulated microRNA-17~92 (miR-17~92) and miR-106a~363 clusters target hCYP19A1 and hGCM1 to inhibit human trophoblast differentiation." in: Molecular and cellular biology, Vol. 33, Issue 9, pp. 1782-96, (2013) (PubMed).

    Drewlo, Czikk, Baczyk, Lye, Kingdom: "Glial cell missing-1 mediates over-expression of tissue inhibitor of metalloproteinase-4 in severe pre-eclamptic placental villi." in: Human reproduction (Oxford, England), Vol. 26, Issue 5, pp. 1025-34, (2011) (PubMed).

    Baczyk, Drewlo, Proctor, Dunk, Lye, Kingdom: "Glial cell missing-1 transcription factor is required for the differentiation of the human trophoblast." in: Cell death and differentiation, Vol. 16, Issue 5, pp. 719-27, (2009) (PubMed).

  • 抗原
    GCM1 (Glial Cells Missing Homolog 1 (GCM1))
    别名
    GCM1 / GCMA (GCM1 产品)
    别名
    GCM1 antibody, GCM antibody, GCM-1 antibody, GCMA antibody, hGCMa antibody, GCMa antibody, Gcm-rs2 antibody, Gcm1-rs1 antibody, glide antibody, Gcma antibody, glial cells missing homolog 1 antibody, glial cells missing homolog 1 (Drosophila) antibody, GCM1 antibody, Gcm1 antibody
    背景
    GCM1 is a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein.This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-132 D88613.1 1-132 133-2763 AB026493.1 1-2631
    Alias Symbols: GCMA, hGCMa
    Protein Interaction Partner: FBXW2, UBC, SENP1, CAMK1, SUMO1, DUSP23, CREBBP, HDAC5, HDAC4, HDAC3, HDAC1, CUL1, SKP1, UBE2I,
    Protein Size: 436
    分子量
    49 kDa
    基因ID
    8521
    NCBI登录号
    NM_003643, NP_003634
    UniProt
    Q9NP62
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