CHRNA7 抗体 (N-Term)
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- 抗原 See all CHRNA7 抗体
- CHRNA7 (Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7))
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抗原表位
- N-Term
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适用
- 人, 大鼠, 小鼠, Cow
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CHRNA7 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- QGEFQRKLYK ELVKNYNPLE RPVANDSQPL TVYFSLSLLQ IMDVDEKNQV
- 预测反应
- Cow: 93%, Human: 100%, Mouse: 100%, Rat: 100%
- 产品特性
- This is a rabbit polyclonal antibody against CHRNA7. It was validated on Western Blot using a cell lysate as a positive control.
- 纯化方法
- Protein A purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human CHRNA7
- Top Product
- Discover our top product CHRNA7 Primary Antibody
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 502 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- CHRNA7 (Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7))
- 别名
- CHRNA7 (CHRNA7 产品)
- 别名
- CHRNA7-2 antibody, NACHRA7 antibody, dZ70B1.1 antibody, Acra7 antibody, alpha7 antibody, BTX antibody, NARAD antibody, nAChRa7 antibody, CHRNA7 antibody, cholinergic receptor nicotinic alpha 7 subunit antibody, neuronal acetylcholine receptor subunit alpha-7 antibody, cholinergic receptor, nicotinic, alpha 7 (neuronal) antibody, cholinergic receptor, nicotinic, alpha polypeptide 7 antibody, cholinergic receptor, nicotinic, alpha 7 antibody, CHRNA7 antibody, LOC100374356 antibody, chrna7 antibody, Chrna7 antibody, LOC100060521 antibody
- 背景
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The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. CHRNA7 is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from CHRNA7 and a novel FAM7A gene.
Alias Symbols: NACHRA7, CHRNA7-2
Protein Interaction Partner: ATXN1, ADCY6, PIK3R1, APP, FYN,
Protein Size: 502 - 分子量
- 56 kDa
- 基因ID
- 1139
- NCBI登录号
- NM_000746, NP_000737
- UniProt
- P36544
- 途径
- Synaptic Membrane
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