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CHRNA7 抗体 (N-Term)

CHRNA7 适用: 人, 大鼠, 小鼠, Cow WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2792250
发货至: 中国
  • 抗原 See all CHRNA7 抗体
    CHRNA7 (Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7))
    抗原表位
    • 15
    • 14
    • 8
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
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    • 1
    • 1
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    • 1
    N-Term
    适用
    • 62
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    • 31
    • 7
    • 5
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    • 4
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    • 2
    • 1
    人, 大鼠, 小鼠, Cow
    宿主
    • 52
    • 12
    • 2
    克隆类型
    • 52
    • 13
    多克隆
    标记
    • 28
    • 5
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    • 3
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    • 2
    • 1
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    • 1
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    • 1
    • 1
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    • 1
    This CHRNA7 antibody is un-conjugated
    应用范围
    • 54
    • 23
    • 13
    • 13
    • 10
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    序列
    QGEFQRKLYK ELVKNYNPLE RPVANDSQPL TVYFSLSLLQ IMDVDEKNQV
    预测反应
    Cow: 93%, Human: 100%, Mouse: 100%, Rat: 100%
    产品特性
    This is a rabbit polyclonal antibody against CHRNA7. It was validated on Western Blot using a cell lysate as a positive control.
    纯化方法
    Protein A purified
    免疫原
    The immunogen is a synthetic peptide directed towards the N terminal region of human CHRNA7
    Top Product
    Discover our top product CHRNA7 Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 502 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • 抗原
    CHRNA7 (Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7))
    别名
    CHRNA7 (CHRNA7 产品)
    别名
    CHRNA7-2 antibody, NACHRA7 antibody, dZ70B1.1 antibody, Acra7 antibody, alpha7 antibody, BTX antibody, NARAD antibody, nAChRa7 antibody, CHRNA7 antibody, cholinergic receptor nicotinic alpha 7 subunit antibody, neuronal acetylcholine receptor subunit alpha-7 antibody, cholinergic receptor, nicotinic, alpha 7 (neuronal) antibody, cholinergic receptor, nicotinic, alpha polypeptide 7 antibody, cholinergic receptor, nicotinic, alpha 7 antibody, CHRNA7 antibody, LOC100374356 antibody, chrna7 antibody, Chrna7 antibody, LOC100060521 antibody
    背景
    The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. CHRNA7 is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from CHRNA7 and a novel FAM7A gene.
    Alias Symbols: NACHRA7, CHRNA7-2
    Protein Interaction Partner: ATXN1, ADCY6, PIK3R1, APP, FYN,
    Protein Size: 502
    分子量
    56 kDa
    基因ID
    1139
    NCBI登录号
    NM_000746, NP_000737
    UniProt
    P36544
    途径
    Synaptic Membrane
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